Comparison of three different risk-stratification models for predicting lymph node involvement in endometrioid endometrial cancer clinically confined to the uterus.
Comparison of three different risk-stratification models for predicting lymph node involvement in endometrioid endometrial cancer clinically confined to the uterus.
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DOI：
10.3802/jgo.2017.28.e78
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发表时间：
2017-11
影响因子：
3.9
通讯作者：
Ayhan A
中科院分区：
文献类型：
--
作者：
Korkmaz V;Meydanli MM;Yalçın I;Sarı ME;Sahin H;Kocaman E;Haberal A;Dursun P;Güngör T;Ayhan A
To compare the clinical validity of the Gynecologic Oncology Group-99 (GOG-99), the Mayo-modified and the European Society for Medical Oncology (ESMO)-modified criteria for predicting lymph node (LN) involvement in women with endometrioid endometrial cancer (EC) clinically confined to the uterus. A total of 625 consecutive women who underwent comprehensive surgical staging for endometrioid EC clinically confined to the uterus were divided into low- and high-risk groups according to the GOG-99, the Mayo-modified, and the ESMO-modified criteria. Lymphovascular space invasion is the cornerstone of risk stratification according to the ESMO-modified criteria. These 3 risk stratification models were compared in terms of predicting LN positivity. Systematic LN dissection was achieved in all patients included in the study. LN involvement was detected in 70 (11.2%) patients. LN involvement was correctly estimated in 51 of 70 LN-positive patients according to the GOG-99 criteria (positive likelihood ratio [LR+], 3.3; negative likelihood ratio [LR−], 0.4), 64 of 70 LN-positive patients according to the ESMO-modified criteria (LR+, 2.5; LR−, 0.13) and 69 of the 70 LN-positive patients according to the Mayo-modified criteria (LR+, 2.2; LR−, 0.03). The area under curve of the Mayo-modified, the GOG-99 and the ESMO-modified criteria was 0.763, 0.753, and 0.780, respectively. The ESMO-modified classification seems to be the risk-stratification model that most accurately predicts LN involvement in endometrioid EC clinically confined to the uterus. However, the Mayo-modified classification may be an alternative model to achieve a precise balance between the desire to prevent over-treatment and the ability to diagnose LN involvement.
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影响因子：
9.3
作者：
Bossuyt, PM;Reitsma, JB;de Vet, HCW
通讯作者：
de Vet, HCW
影响因子：
9.8
作者：
Mariani, A;Webb, MJ;Podratz, KC
通讯作者：
Podratz, KC
影响因子：
4.7
作者：
Akbayir, Ozgur;Corbacioglu, Aytul;Cetin, Ahmet
通讯作者：
Cetin, Ahmet
影响因子：
8.8
作者：
Bendifallah, S.;Canlorbe, G.;Collinet, P.;Arsene, E.;Huguet, F.;Coutant, C.;Hudry, D.;Graesslin, O.;Raimond, E.;Touboul, C.;Darai, E.;Ballester, M.
通讯作者：
Ballester, M.
影响因子：
2.6
作者：
Mahdi, Haider;Munkarah, Adnan R.;Moslemi-Kebria, Mehdi
通讯作者：
Moslemi-Kebria, Mehdi