Spontaneous transformation of cynomolgus mesenchymal stem cells in vitro: further confirmation by short tandem repeat analysis.

Spontaneous transformation of cynomolgus mesenchymal stem cells in vitro: further confirmation by short tandem repeat analysis.
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食蟹猴间充质干细胞体外自发转化:通过短串联重复分析进一步证实。

DOI:
10.1016/j.yexcr.2011.12.012
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发表时间:
2012-03
期刊:
Exp Cell Res
影响因子:
--
通讯作者:
Chen Z
Chen Z
中科院分区:
其他
文献类型:
--
作者:
Ren Z;Zhang YA;Chen Z

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相似文献

间充质干细胞(MSC)是否可以在培养物中进行自发转化仍然是一个备受争议的问题。最近,两个小组撤回了之前的出版物,因为发现所声称的转化细胞实际上污染了癌细胞,这需要在现场对转化细胞进行更严格的鉴定。在本研究中,我们继续之前发现的食蟹猴间充质干细胞自发转化的发现,并使用短串联重复分析提供了进一步的证据,证明转化的间充质干细胞确实源自食蟹猴间充质干细胞。
It remains a highly debatable issue whether mesenchymal stem cells (MSCs) can undergo spontaneous transformation in culture. Recently, two groups retracted their previous publications due to the finding that the claimed transformed cells are actually contaminating cancer cells, which calls for a more stringent identification of transformed cells in the field. In this study, we continued with our previous finding of spontaneous transformation of cynomolgus MSCs and provided further evidence using short tandem repeat analysis that the transformed mesenchymal stem cells were indeed derived from cynomolgus MSCs.
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