Bacterial stress defense: the crucial role of ribosome speed
Bacterial stress defense: the crucial role of ribosome speed
复制标题
细菌应激防御：核糖体速度的关键作用
DOI：
10.1007/s00018-019-03304-0
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发表时间：
2019-09
影响因子：
8
通讯作者：
Xiongfeng Dai
中科院分区：
文献类型：
--
作者：
Manlu Zhu;Xiongfeng Dai
在自然界中，细菌不断适应各种压力条件。及时激活应激反应程序对于细菌在应激条件下顺利生存至关重要。应激反应需要许多防御蛋白的从头合成，通常由特定的调节因子在转录水平上激活。然而，整体蛋白质翻译状态对应激反应的影响在很大程度上被忽视了。翻译能力受到翻译核糖体数量和翻译延伸率的限制。最近的研究表明，某些环境应激源（例如氧化应激）可能会导致平移延伸过程减慢甚至完全停滞，从而严重损害细菌的应激反应进程。核糖体延伸率的维持对于应激防御蛋白的及时合成至关重要，成为限制细菌在某些应激条件下生存的生理瓶颈。在这里，我们简要总结了营养剥夺和氧化应激两种不同应激条件下细菌翻译状态的一些最新进展。我们进一步讨论了压力期间细菌翻译调控的几个重要的开放性问题。核糖体翻译应与传统的转录调控并行研究，以便更好地了解细菌应激防御。
In nature, bacteria are constantly adapting to various stressful conditions. Timely activation of stress response programs is crucial for bacteria to smoothly survive under stressful conditions. Stress response, demanding the de novo synthesis of many defense proteins, is generally activated at the transcriptional level by specific regulators. However, the effect of the global protein translational status on stress response has been largely overlooked. The translational capacity is limited by the number of translating ribosomes and the translational elongation rate. Recent work has shown that certain environmental stressors (e.g. oxidative stress) could severely compromise the stress response progress of bacteria by causing either slow-down or even complete stalling of the translational elongation process. The maintenance of ribosome elongation rate, being crucial for timely synthesis of stress defense proteins, becomes the physiological bottleneck that limits the survival of bacteria in some stressful conditions. Here, we briefly summarize some recent progress on the translational status of bacteria under two distinct stress conditions, nutrient deprivation and oxidative stress. We further discuss several important open questions on the translational regulation of bacteria during stress. The ribosome translation should be investigated in parallel with traditional transcriptional regulation in order to gain a better understanding on bacterial stress defense.
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影响因子：
28.3
作者：
Li SH;Li Z;Park JO;King CG;Rabinowitz JD;Wingreen NS;Gitai Z
通讯作者：
Gitai Z
DOI：
10.1073/pnas.0606384103
发表时间：
2006-09-19
影响因子：
11.1
作者：
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影响因子：
28.3
作者：
Manlu Zhu;Matteo Mori;Terence hwa;Xiongfeng Dai
通讯作者：
Xiongfeng Dai
影响因子：
3.6
作者：
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通讯作者：
U. Vogel;M. Sørensen;S. Pedersen;K. Jensen;M. Kilstrup