Twin studies of brain, cognition, and behavior.
Twin studies of brain, cognition, and behavior.
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DOI：
10.1016/j.neubiorev.2020.04.009
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发表时间：
2020-08
影响因子：
8.2
通讯作者：
Hewitt JK
中科院分区：
文献类型：
--
作者：
Hewitt JK
For many of the papers in this volume, and most of the studies reviewed within those papers, the empirical evidence presented and analyzed is primarily about the heritability of, and environmental influences on, individual phenotypes. These data and analyses are an important first step in any study of the causes of individual differences, whether for quantitative traits or for clinical disorders.As we have learned in the era of genome-wide studies of variation (eg genome wide association studies (GWAS)), twin and family study heritability estimates provide an important benchmark against which to evaluate emerging knowledge from genomic research. Without prior twin and family studies, there would likely have been no appreciation of themissing heritability’in common variant GWAS results and we might have concluded, prematurely and incorrectly, that heritability was usually very low for complex traits and most familial similarity was attributable to shared family environments. As it is, twin studies have provided us with higher, probably upper bound, heritability estimates and so motivated the pursuit of contributions to heritable variation from rare variants, copy number variation, non-additivity, and other sources. It has recently been demonstrated that the twin and family study estimates of the heritability of adult height can be fully recovered using whole genome sequence data that take proper account of the impact of low frequency and rare variants, especially those in low linkage disequilibrium with common SNP variants used in traditional GWAS (Wainschtein et al, 2019). Thus, the papers in this special issue that provide basic information about the heritability of a range of traits and conditions do provide important benchmark information. These papers include Abramson et al on Emotional and cognitive empathy, Valero et al on Sleep quality and duration, Picardi et al on Attachment, and Twito and Knafo-Noam on Values.
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影响因子：
4.7
作者：
Iacono WG;Heath AC;Hewitt JK;Neale MC;Banich MT;Luciana MM;Madden PA;Barch DM;Bjork JM
通讯作者：
Bjork JM
影响因子：
2.6
作者：
Hatemi, Peter K.;Medland, Sarah E.;Martin, Nicholas G.
通讯作者：
Martin, Nicholas G.
影响因子：
5.6
作者：
Winiger, Evan A.;Huggett, Spencer B.;Hewitt, John K.
通讯作者：
Hewitt, John K.
DOI：
10.1073/pnas.1711233114
发表时间：
2017-10-03
影响因子：
11.1
作者：
Berer, Kerstin;Gerdes, Lisa Ann;Wekerle, Hartmut
通讯作者：
Wekerle, Hartmut
影响因子：
9.8
作者：
Selzam, Saskia;Ritchie, Stuart J.;Plomin, Robert
通讯作者：
Plomin, Robert