The utility of twins in developmental cognitive neuroscience research: How twins strengthen the ABCD research design.
The utility of twins in developmental cognitive neuroscience research: How twins strengthen the ABCD research design.
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DOI：
10.1016/j.dcn.2017.09.001
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发表时间：
2018-08
影响因子：
4.7
通讯作者：
Bjork JM
中科院分区：
文献类型：
--
作者：
Iacono WG;Heath AC;Hewitt JK;Neale MC;Banich MT;Luciana MM;Madden PA;Barch DM;Bjork JM
ABCD双胞胎研究将阐明遗传和环境对儿童心理和身体健康结果的广泛影响，包括物质使用、大脑和行为发育以及它们之间的相互关系。在多重评估的推动下，同卵双胞胎和异卵双胞胎内部和之间的比较，提供了关于遗传和环境对发育关联的贡献的信息，并使因果假设的检验比涉及无血缘关系的儿童的比较更有力。因此，800对同性双胞胎的子研究被嵌入到整个青少年大脑和认知发展(ABCD)设计中。ABCD双胞胎中心由明尼苏达州、科罗拉多州、弗吉尼亚州和密苏里州的四个领先的双胞胎研究中心组成。每个网站招收200对双胞胎和单身人士。这对双胞胎是从2006-2008年间每个州的所有双胞胎出生登记处招募的。与ABCD研究的其余部分一样，每个地点的单身人士都是按照同样的学校程序招募的。本文介绍了ABCD双胞胎研究的背景和基本原理，双胞胎对的确定和在每个地点的实施策略，以及为量化遗传和环境影响并检验对ABCD研究目标至关重要的假设而提出的分析策略的细节。
The ABCD twin study will elucidate the genetic and environmental contributions to a wide range of mental and physical health outcomes in children, including substance use, brain and behavioral development, and their interrelationship. Comparisons within and between monozygotic and dizygotic twin pairs, further powered by multiple assessments, provide information about genetic and environmental contributions to developmental associations, and enable stronger tests of causal hypotheses, than do comparisons involving unrelated children. Thus a sub-study of 800 pairs of same-sex twins was embedded within the overall Adolescent Brain and Cognitive Development (ABCD) design. The ABCD Twin Hub comprises four leading centers for twin research in Minnesota, Colorado, Virginia, and Missouri. Each site is enrolling 200 twin pairs, as well as singletons. The twins are recruited from registries of all twin births in each State during 2006–2008. Singletons at each site are recruited following the same school-based procedures as the rest of the ABCD study. This paper describes the background and rationale for the ABCD twin study, the ascertainment of twin pairs and implementation strategy at each site, and the details of the proposed analytic strategies to quantify genetic and environmental influences and test hypotheses critical to the aims of the ABCD study.
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影响因子：
5.7
作者：
Chiang MC;McMahon KL;de Zubicaray GI;Martin NG;Hickie I;Toga AW;Wright MJ;Thompson PM
通讯作者：
Thompson PM
DOI：
10.1073/pnas.1308091110
发表时间：
2013-10-15
影响因子：
11.1
作者：
Chen, Chi-Hua;Fiecas, Mark;Kremen, William S.
通讯作者：
Kremen, William S.
DOI：
10.1126/science.1215330
发表时间：
2012-03-30
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Chen CH;Gutierrez ED;Thompson W;Panizzon MS;Jernigan TL;Eyler LT;Fennema-Notestine C;Jak AJ;Neale MC;Franz CE;Lyons MJ;Grant MD;Fischl B;Seidman LJ;Tsuang MT;Kremen WS;Dale AM
通讯作者：
Dale AM
影响因子：
3.8
作者：
Boker, SM;Nesselroade, JR
通讯作者：
Nesselroade, JR
影响因子：
3.7
作者：
Carlson, SR;Iacono, WG;McGue, M
通讯作者：
McGue, M