Metallothionein and the biology of aging.
Metallothionein and the biology of aging.
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DOI：
10.1016/j.arr.2010.09.007
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发表时间：
2011-01
影响因子：
13.1
通讯作者：
Swindell, William R.
中科院分区：
文献类型：
--
作者：
Swindell, William R.
金属硫蛋白（MT）是一种具有抗凋亡特性的低分子量蛋白，已被证明在体外清除自由基。MT还没有在衰老生物学的背景下进行广泛的研究。因此，本综述的目的是讨论与基本衰老机制相关的MT研究结果，并引起人们对MT在促进长寿干预中的可能作用的关注。MT是少数几种蛋白质之一，当过度表达时，已被证明可以延长小鼠的寿命。MT还可以防止高脂肪饮食小鼠的肥胖发展以及饮食引起的氧化应激损伤。MT的丰度对热量限制（CR）和胰岛素/胰岛素样信号传导（IIS）途径的抑制有响应，在禁食和CR喂养的小鼠、长寿矮鼠、CR条件下维持的蠕虫和长寿daf-2突变蠕虫的组织中观察到MT基因表达升高。MT在这些系统中的失调可能对衰老结果有组织特异性影响。因此，需要进一步的研究来了解MT如何促进无脊椎动物和小鼠对CR的反应以及衰老研究人员所研究的内分泌突变。
Metallothionein (MT) is a low molecular weight protein with anti-apoptotic properties that has been demonstrated to scavenge free radicals in vitro. MT has not been extensively investigated within the context of aging biology. The purpose of this review, therefore, is to discuss findings on MT that are relevant to basic aging mechanisms and to draw attention to the possible role of MT in pro-longevity interventions. MT is one of just a handful of proteins that, when overexpressed, has been demonstrated to increase mouse lifespan. MT also protects against development of obesity in mice provided a high fat diet as well as diet-induced oxidative stress damage. Abundance of MT is responsive to caloric restriction (CR) and inhibition of the insulin / insulin-like signaling (IIS) pathway, and elevated MT gene expression has been observed in tissues from fasted and CR-fed mice, long-lived dwarf mice, worms maintained under CR conditions, and long-lived daf-2 mutant worms. The dysregulation of MT in these systems is likely to have tissue-specific effects on aging outcomes. Further investigation will therefore be needed to understand how MT contributes to the response of invertebrates and mice to CR and the endocrine mutations studied by aging researchers.
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