Local irrigation with tissue factor pathway inhibitor inhibits intimal hyperplasia induced by arterial interventions.
Local irrigation with tissue factor pathway inhibitor inhibits intimal hyperplasia induced by arterial interventions.
复制标题
用组织因子途径抑制剂进行局部冲洗可抑制动脉干预引起的内膜增生。
DOI：
10.1001/archsurg.1996.01430220080018
复制
发表时间：
1996
影响因子：
--
通讯作者：
R. Khouri
中科院分区：
文献类型：
--
作者：
D. Brown;N. Kania;E. Choi;L. Lantieri;E. Pasia;T. Wun;R. Khouri
目的
评价组织因子途径抑制物（TFPI）局部灌注抑制内膜切除术或球囊血管成形术后血管新生内膜病变形成的能力。
设计
对新西兰白色家兔的颈总动脉进行内膜切除术或球囊血管成形术。
干预
在恢复血流之前，用1 mL含TFPI（100 μ g/mL [TFPI组，n = 10]）或不含TFPI（对照组，n = 10）的Dulbecco磷酸盐缓冲盐水冲洗血管腔。
主要观察指标
从弹性蛋白染色切片确定新生内膜形成面积和内膜与中膜面积的比率（I/M）。
结果
术后2周新生内膜面积和I/M比值无显著差异。然而，在4周时，与对照组相比，血管成形术和内膜切除术后，TFPI治疗的血管显示出新生内膜病变和I/M比值显著降低。透射电子显微镜检查显示TFPI处理血管内膜表面缺乏血小板聚集和血栓形成。
结论
在动脉介入治疗时用TFPI局部冲洗可抑制球囊血管成形术或内膜切除术后的内膜增生。我们假设TFPI与受损血管表面结合，抑制促进内膜增生的血栓事件级联反应。
OBJECTIVE
To evaluate the capacity of local irrigation with tissue factor pathway inhibitor (TFPI) to inhibit vessels from neointimal lesion formation following intimectomy or balloon angioplasty.
DESIGN
The common carotid arteries in New Zealand white rabbits were subjected to either intimectomy or balloon angioplasty.
INTERVENTION
Before restoring blood flow, the lumina of the vessels were irrigated with 1 mL of Dulbecco phosphate-buffered saline either with TFPI (100 micrograms/mL [TFPI group, n = 10]) or without TFPI (control group, n = 10).
MAIN OUTCOME MEASURES
The area of neointimal formation and the ratio of the intimal to medial areas (I/M) were determined from elastin-stained sections.
RESULTS
The area of neointima and the I/M ratio were not significantly different at 2 weeks postoperatively. However, at 4 weeks, TFPI-treated vessels demonstrated a significant reduction in the neointimal lesion and the I/M ratio compared with those of controls, following both angioplasty and intimectomy. Transmission electron microscopy showed a lack of platelet aggregation and thrombus formation at the intimal surface in the TFPI-treated vessels.
CONCLUSIONS
Local irrigation with TFPI at the time of arterial interventional therapy inhibits intimal hyperplasia following either balloon angioplasty or intimectomy. We hypothesize that TFPI binds to the injured vessel surface and inhibits the cascade of thrombotic events that promote intimal hyperplasia.
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影响因子：
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作者：
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DOI：
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发表时间：
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影响因子：
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