Subclinical Cardiovascular Disease and Death, Dementia, and Coronary Heart Disease in Patients 80+ Years.
Subclinical Cardiovascular Disease and Death, Dementia, and Coronary Heart Disease in Patients 80+ Years.
复制标题
DOI：
10.1016/j.jacc.2015.12.034
复制
发表时间：
2016-03-08
影响因子：
24
通讯作者：
Newman AB
中科院分区：
文献类型：
--
作者：
Kuller LH;Lopez OL;Mackey RH;Rosano C;Edmundowicz D;Becker JT;Newman AB
The successful prevention and treatment of CHD and stroke has resulted in substantial increase in longevity with a subsequent growth in the population of older individuals at risk for dementia. We evaluated the relationship of coronary and other peripheral atherosclerosis to risk of death, dementia, and CHD in the very elderly. Because of substantial differences in extent of vascular disease between men and women, sex- and race-specific analyses were included with a specific focus for women with low CAC Agatston scores. We evaluated the relationship between measures of subclinical measures of CVD (CAC, carotid intimal medial thickness, stenosis and ankle brachial index) and risk of dementia, CHD, and total mortality in 532 participants of the Cardiovascular Health Study-Cognition Study from 1998–99 (mean age 80) to 2012–13 (mean age 93). Thirty-six percent of participants had CAC scores >400. Women and African-Americans had lower CAC scores. Few men had low amounts of CAC. The extent of CAC scores or the number of coronary calcifications was directly related to age-adjusted total mortality and CHD. Age-specific incidence of dementia was higher than for CHD. Only about 25% of deaths were due to CHD and 16% to dementia. Approximately 64% of all deaths had diagnosis of dementia prior to death. White women with low CAC scores had a significant decreased incidence of dementia. Incidence of dementia in individuals age 80+ is greater than that for CHD. CAC, as a marker of atherosclerosis, is a determinant of mortality and the risk of CHD and MI. White women with low CAC scores had a significant decreased risk of dementia. A very important unanswered question, especially in the elderly age 80+, is whether prevention of atherosclerosis and its complications is associated with less extent of AD pathology and dementia.
登录
查看更多内容
影响因子：
37.8
作者：
Go AS;Mozaffarian D;Roger VL;Benjamin EJ;Berry JD;Blaha MJ;Dai S;Ford ES;Fox CS;Franco S;Fullerton HJ;Gillespie C;Hailpern SM;Heit JA;Howard VJ;Huffman MD;Judd SE;Kissela BM;Kittner SJ;Lackland DT;Lichtman JH;Lisabeth LD;Mackey RH;Magid DJ;Marcus GM;Marelli A;Matchar DB;McGuire DK;Mohler ER 3rd;Moy CS;Mussolino ME;Neumar RW;Nichol G;Pandey DK;Paynter NP;Reeves MJ;Sorlie PD;Stein J;Towfighi A;Turan TN;Virani SS;Wong ND;Woo D;Turner MB;American Heart Association Statistics Committee and Stroke Statistics Subcommittee
通讯作者：
American Heart Association Statistics Committee and Stroke Statistics Subcommittee
影响因子：
24
作者：
Gaita, Fiorenzo;Corsinovi, Laura;Scaglione, Marco
通讯作者：
Scaglione, Marco
影响因子：
14
作者：
Bos, Daniel;Vernooij, Meike W.;Ikram, M. Arfan
通讯作者：
Ikram, M. Arfan
影响因子：
--
作者：
Kovacic, Jason C.;Fuster, Valentin
通讯作者：
Fuster, Valentin
影响因子：
37.8
作者：
KULLER, LH;SHEMANSKI, L;TRACY, R
通讯作者：
TRACY, R