Associations between vaginal bacteria and levels of vaginal defensins in pregnant women.
Associations between vaginal bacteria and levels of vaginal defensins in pregnant women.
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DOI：
10.1016/j.ajog.2012.11.019
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发表时间：
2013-02
影响因子：
9.8
通讯作者：
Nelson, Deborah B.
中科院分区：
文献类型：
--
作者：
Mitchell, Caroline;Gottsch, Michelle L.;Liu, Congzhou;Fredricks, David N.;Nelson, Deborah B.
我们评估了孕妇阴道防御素浓度和BV相关细菌种类的水平。使用qPCR检测妊娠期间两次访视的自我采集阴道拭子中的9种细菌。通过ELISA测量β防御素2（HBD 2）、HBD 3和α防御素1-3（HNP 1 -3）。我们的126名参与者主要是非洲裔美国人（60%），入组时的平均胎龄为10周（±3），随访时为25周（± 6）。入组时，BV患病率为74%（94/126），随访时降至60%（75/126）。入组时，BV女性患者的HBD 3浓度显著较低（2.64 ± 0.91 vs. 3.25 ± 0.99 log 10 pg/mL; p = 0.003）。较高浓度的阴道变形菌、BVAB 1和BVAB 2与显著较低浓度的HBD 3相关（p < 0.01）。在孕妇中，BV与较低的HBD 3阴道浓度相关，但与HBD 2或HNP 1 -3无关。
We evaluated vaginal defensin concentrations and levels of BV-associated bacterial species in pregnant women. Self-collected vaginal swabs from two visits during pregnancy were tested with qPCR for nine bacterial species. Beta defensin 2 (HBD2), HBD3 and alpha defensins 1–3 (HNP1–3) were measured by ELISA. Our 126 participants were primarily African American (60%), had a mean gestational age at enrollment of 10 weeks (±3) and at follow-up of 25 weeks (± 6). At enrollment, prevalence of BV was 74% (94/126), which decreased to 60% (75/126) at follow-up. At enrollment, HBD3 concentrations were significantly lower in women with BV (2.64 + 0.91 vs. 3.25 + 0.99 log10 pg/mL; p = 0.003). Higher concentrations of Atopobium vaginae, BVAB1 and BVAB2 were associated with significantly lower concentrations of HBD3 (p < 0.01). BV was associated with lower vaginal concentrations of HBD3, but not HBD2 or HNP1–3, in pregnant women.
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影响因子：
3.7
作者：
Khot, Prasanna D.;Ko, Daisy L.;Hackman, Robert C.;Fredricks, David N.
通讯作者：
Fredricks, David N.
影响因子：
2.3
作者：
Nelson, Deborah B.;Bellamy, Scarlett;Friedenberg, Frank K.
通讯作者：
Friedenberg, Frank K.
影响因子：
3.9
作者：
Hardwick, Robert J.;Machado, Lee R.;Zuccherato, Luciana W.;Antolinos, Suzanne;Xue, Yali;Shawa, Nyambura;Gilman, Robert H.;Cabrera, Lilia;Berg, Douglas E.;Tyler-Smith, Chris;Kelly, Paul;Tarazona-Santos, Eduardo;Hollox, Edward J.
通讯作者：
Hollox, Edward J.
影响因子：
7.2
作者：
Balu, RB;Savitz, DA;Heine, RP
通讯作者：
Heine, RP
影响因子：
3.1
作者：
Moranta, David;Regueiro, Veronica;Bengoechea, Jose A.
通讯作者：
Bengoechea, Jose A.