Metal Chelation Modulates Phototherapeutic Properties of Mitoxantrone-Loaded Porphyrin-Phospholipid Liposomes.
Metal Chelation Modulates Phototherapeutic Properties of Mitoxantrone-Loaded Porphyrin-Phospholipid Liposomes.
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DOI：
10.1021/acs.molpharmaceut.5b00653
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发表时间：
2016-02-01
影响因子：
4.9
通讯作者：
Lovell JF
中科院分区：
文献类型：
--
作者：
Carter KA;Wang S;Geng J;Luo D;Shao S;Lovell JF
含有卟啉-磷脂（PoP）的脂质体可以在近红外激光照射下释放被包裹的内容物。在这里，我们研究了铜或锌螯合到PoP中的影响。含有10摩尔% hphh -脂质的Cu（II）和Zn(II) PoP脂质体表现出独特的光物理性质，并在近红外光下释放被捕获的货物。Cu-PoP脂质体在辐照下表现出最小的荧光和减少活性氧的产生。Zn-PoP脂质体保留了荧光和单线态产氧特性，但在激光照射下迅速自漂。与自由碱形式相比，Cu-和Zn-PoP脂质体在小鼠中的光毒性均有所降低。当负载米托蒽醌并以5mg /kg的剂量静脉给药给人胰腺癌异种移植小鼠时，药物与光治疗（针对这种特定剂量和配方）之间的协同作用通过金属- pop脂质体实现。药物-光间隔影响光化学治疗的疗效和安全性。
Liposomes incorporating porphyrin–phospholipid (PoP) can be formulated to release entrapped contents in response to near infrared (NIR) laser irradiation. Here, we examine effects of chelating copper or zinc into the PoP. Cu(II) and Zn(II) PoP liposomes, containing 10 molar % HPPH-lipid, exhibited unique photophysical properties and released entrapped cargo in response to NIR light. Cu-PoP liposomes exhibited minimal fluorescence and reduced production of reactive oxygen species upon irradiation. Zn-PoP liposomes retained fluorescence and singlet oxygen generation properties, however they rapidly self-bleached under laser irradiation. Compared to the free base form, both Cu- and Zn-PoP liposomes exhibited reduced phototoxicity in mice. When loaded with mitoxantrone and administered intravenously at 5 mg/kg to mice bearing human pancreatic cancer xenografts, synergistic effects between the drug and the light treatment (for this particular dose and formulation) were realized with metallo-PoP liposomes. The drug-light-interval affected chemophototherapy efficacy and safety.
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影响因子：
6.6
作者：
Caldorera-Moore M;Guimard N;Shi L;Roy K
通讯作者：
Roy K
影响因子：
16.6
作者：
Carter, Kevin A.;Shao, Shuai;Hoopes, Matthew I.;Luo, Dandan;Ahsan, Bilal;Grigoryants, Vladimir M.;Song, Wentao;Huang, Haoyuan;Zhang, Guojian;Pandey, Ravindra K.;Geng, Jumin;Pfeifer, Blaine A.;Scholes, Charles P.;Ortega, Joaquin;Karttunen, Mikko;Lovell, Jonathan F.
通讯作者：
Lovell, Jonathan F.
DOI：
10.1016/j.jconrel.2011.11.029
发表时间：
2012-06-10
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Cern A;Golbraikh A;Sedykh A;Tropsha A;Barenholz Y;Goldblum A
通讯作者：
Goldblum A
影响因子：
3.4
作者：
Charrois, GJR;Allen, TM
通讯作者：
Allen, TM
影响因子：
15
作者：
Fan, J;Whiteford, JA;Fleischer, EB
通讯作者：
Fleischer, EB