Designer nanoparticles: incorporating size, shape and triggered release into nanoscale drug carriers.
Designer nanoparticles: incorporating size, shape and triggered release into nanoscale drug carriers.
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DOI：
10.1517/17425240903579971
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发表时间：
2010-04
影响因子：
6.6
通讯作者：
Roy K
中科院分区：
文献类型：
--
作者：
Caldorera-Moore M;Guimard N;Shi L;Roy K
尽管在通过微和纳米载体递送治疗剂方面取得了重大进展，但对体内生物分布和疾病反应性药物释放的精确控制一直难以实现。这对下一代药物输送装置的成功至关重要，因为设计用于干扰细胞功能的新药必须有效和特异性地输送到患病细胞。实现这一目标的主要限制是我们有限的粒子合成方法，特别是在纳米尺度上。最近在生成形状特异性纳米载体方面的进展，以及将刺激响应释放与纳米级递送装置相结合的潜力，在克服这些限制方面显示出很大的希望。在这里，我们讨论了制造技术的最新进展如何允许合成高度单分散，刺激响应，携带精确几何形状的药物纳米颗粒。我们还回顾了颗粒特性，特别是形状和刺激反应性，如何影响生物分布，细胞摄取和药物释放。读者介绍了智能药物纳米载体的最新发展和新的纳米制造方法，可以与疾病反应性生物材料相结合。这将为控制粒子几何形状和将刺激反应材料纳入药物递送的重要性提供见解。
Although significant progress has been made in delivering therapeutic agents through micro and nanocarriers, precise control over in vivo biodistribution and disease-responsive drug release has been difficult to achieve. This is critical for the success of next generation drug delivery devices, since newer drugs, designed to interfere with cellular functions, must be efficiently and specifically delivered to diseased cells. The major constraint in achieving this has been our limited repertoire of particle synthesis methods, especially at the nanoscale. Recent developments in generating shape-specific nanocarriers and the potential to combine stimuli-responsive release with nanoscale delivery devices show great promise in overcoming these limitations. Here we discuss how recent advancements in fabrication technology allow synthesis of highly monodisperse, stimuli-responsive, drug-carrying nanoparticles of precise geometries. We also review how particle properties, specifically shape and stimuli responsiveness, affect biodistribution, cellular uptake, and drug release. The reader is introduced to recent developments in intelligent drug nanocarriers and new nanofabrication approaches that can be combined with disease-responsive biomaterials. This will provide insight into the importance of controlling particle geometry and incorporating stimuli responsive materials into drug delivery.
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