Pathologic and therapeutic implications for the cell biology of parkin.
Pathologic and therapeutic implications for the cell biology of parkin.
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DOI：
10.1016/j.mcn.2015.02.008
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发表时间：
2015-05
期刊：
影响因子：
--
通讯作者：
LaVoie MJ
中科院分区：
文献类型：
--
作者：
Charan RA;LaVoie MJ
Mutations in the E3 ligase parkin are the most common cause of autosomal recessive Parkinson's disease (PD), but it is believed that parkin dysfunction may also contribute to idiopathic PD. Since its discovery, parkin has been implicated in supporting multiple neuroprotective pathways, many revolving around the maintenance of mitochondrial health quality control and governance of cell survival. Recent advances across the structure, biochemistry, and cell biology of parkin have provided great insights into the etiology of parkin-linked and idiopathic PD and may ultimately generate novel therapeutic strategies to slow or halt disease progression. This review describes the various pathways in which parkin acts and the mechanisms by which parkin may be targeted for therapeutic intervention.
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DOI：
10.1083/jcb.201401070
发表时间：
2014-09-01
期刊：
The Journal of cell biology
影响因子：
--
作者：
Ashrafi G;Schlehe JS;LaVoie MJ;Schwarz TL
通讯作者：
Schwarz TL
影响因子：
3.5
作者：
Chen H;Chan DC
通讯作者：
Chan DC
影响因子：
7.2
作者：
Bosco, Daryl A.;LaVoie, Matthew J.;Ringe, Dagmar
通讯作者：
Ringe, Dagmar
影响因子：
3.5
作者：
Burns, Mark P.;Zhang, Lihua;Moussa, Charbel E. -H.
通讯作者：
Moussa, Charbel E. -H.
影响因子：
3.5
作者：
Cornelissen, Tom;Haddad, Dominik;Vandenberghe, Wim
通讯作者：
Vandenberghe, Wim