Temporal-spatial heterogeneity in animal-environment contact: implications for the exposure and transmission of pathogens.
Temporal-spatial heterogeneity in animal-environment contact: implications for the exposure and transmission of pathogens.
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DOI：
10.1038/srep03112
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发表时间：
2013-11-01
影响因子：
4.6
通讯作者：
Lanzas, Cristina
中科院分区：
文献类型：
--
作者：
Chen, Shi;Sanderson, Michael W.;White, Brad J.;Amrine, David E.;Lanzas, Cristina
接触结构是传染病传播的关键驱动因素，对于环境传播的病原体尚未完全了解和表征。在这项研究中，我们评估了动物接触结构的时空异质性对环境传播病原体动态的影响。我们使用实时动物位置数据来描述动物与特定环境区域之间的接触，用于喂养和浇灌小牛。产生的接触结构在不同的日子和不同的动物之间有所不同。我们将动物和环境异质性整合到基于agent的大肠杆菌O157在牛体内的环境传播模拟模型中，模拟不同地区不同环境细菌浓度下的四种不同情景。模拟结果表明，牛的环境接触结构的异质性影响病原体的流行和与每种环境相关的暴露。我们的研究结果表明，针对细菌浓度高的环境区域，即使是相对较小的区域的干预措施可以有效减轻环境传播的病原体。
Contact structure, a critical driver of infectious disease transmission, is not completely understood and characterized for environmentally transmitted pathogens. In this study, we assessed the effects of temporal and spatial heterogeneity in animal contact structures on the dynamics of environmentally transmitted pathogens. We used real-time animal position data to describe contact between animals and specific environmental areas used for feeding and watering calves. The generated contact structure varied across days and among animals. We integrated animal and environmental heterogeneity into an agent-based simulation model for Escherichia coli O157 environmental transmission in cattle to simulate four different scenarios with different environmental bacteria concentrations at different areas. The simulation results suggest heterogeneity in environmental contact structure among cattle influences pathogen prevalence and exposure associated with each environment. Our findings suggest that interventions that target environmental areas, even relatively small areas, with high bacterial concentration can result in effective mitigation of environmentally transmitted pathogens.
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DOI：
10.3390/s90503586
发表时间：
2009
期刊：
Sensors (Basel, Switzerland)
影响因子：
--
作者：
Handcock RN;Swain DL;Bishop-Hurley GJ;Patison KP;Wark T;Valencia P;Corke P;O'Neill CJ
通讯作者：
O'Neill CJ
影响因子：
1.9
作者：
Breban R
通讯作者：
Breban R
影响因子：
1.4
作者：
Eames, K. T. D.
通讯作者：
Eames, K. T. D.
影响因子：
10.4
作者：
Eisenberg, Joseph N. S.;Desai, Manish A.;Scott, James C.
通讯作者：
Scott, James C.
影响因子：
3.9
作者：
Parham, Paul E.;Ferguson, Neil M.
通讯作者：
Ferguson, Neil M.