Role of environmental persistence in pathogen transmission: a mathematical modeling approach.
Role of environmental persistence in pathogen transmission: a mathematical modeling approach.
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DOI:
10.1007/s00285-012-0520-2
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发表时间:
2013-03
影响因子:
1.9
通讯作者:
Breban R
中科院分区:
文献类型:
--
作者:
Breban R
Although diseases such as influenza, tuberculosis and SARS are transmitted through an environmentally mediated mechanism, most modeling work on these topics is based on the concepts of infectious contact and direct transmission. In this paper we use a paradigm model to show that environmental transmission appears like direct transmission in the case where the pathogen persists little time in the environment. Furthermore, we formulate conditions for the validity of this modeling approximation and we illustrate them numerically for the cases of cholera and influenza. According to our results based on recently published parameter estimates, the direct transmission approximation fails for both cholera and influenza. While environmental transmission is typically chosen over direct transmission in modeling cholera, this is not the case for influenza.
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DOI:
10.1073/pnas.0600166103
发表时间:
2006-03-21
影响因子:
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DOI:
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发表时间:
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期刊:
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