Role of environmental persistence in pathogen transmission: a mathematical modeling approach.

Role of environmental persistence in pathogen transmission: a mathematical modeling approach.
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DOI:
10.1007/s00285-012-0520-2
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发表时间:
2013-03
影响因子:
1.9
通讯作者:
Breban R
Breban R
中科院分区:
数学4区
文献类型:
--
作者:
Breban R

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虽然流感、肺结核和SARS等疾病是通过环境介导的机制传播的,但这些主题的大多数建模工作都是基于传染性接触和直接传播的概念。在本文中,我们使用一个范例模型来表明,环境传播出现像直接传播的情况下,病原体在环境中持续时间很短。此外,我们制定的有效性,这种建模近似的条件,我们用数字说明霍乱和流感的情况下。根据我们最近发表的参数估计的基础上的结果,直接传播近似失败的霍乱和流感。虽然在模拟霍乱时通常选择环境传播而不是直接传播,但流感的情况并非如此。
Although diseases such as influenza, tuberculosis and SARS are transmitted through an environmentally mediated mechanism, most modeling work on these topics is based on the concepts of infectious contact and direct transmission. In this paper we use a paradigm model to show that environmental transmission appears like direct transmission in the case where the pathogen persists little time in the environment. Furthermore, we formulate conditions for the validity of this modeling approximation and we illustrate them numerically for the cases of cholera and influenza. According to our results based on recently published parameter estimates, the direct transmission approximation fails for both cholera and influenza. While environmental transmission is typically chosen over direct transmission in modeling cholera, this is not the case for influenza.
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