A decline in the incidence of invasive non-typhoidal Salmonella infection in The Gambia temporally associated with a decline in malaria infection.
A decline in the incidence of invasive non-typhoidal Salmonella infection in The Gambia temporally associated with a decline in malaria infection.
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DOI：
10.1371/journal.pone.0010568
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发表时间：
2010-05-11
期刊：
影响因子：
3.7
通讯作者：
Greenwood BM
中科院分区：
文献类型：
--
作者：
Mackenzie G;Ceesay SJ;Hill PC;Walther M;Bojang KA;Satoguina J;Enwere G;D'Alessandro U;Saha D;Ikumapayi UN;O'Dempsey T;Mabey DC;Corrah T;Conway DJ;Adegbola RA;Greenwood BM
疟疾是儿童侵袭性非伤寒沙门氏菌(NTS)感染的危险因素。在过去10年中，冈比亚的疟疾感染指数大幅下降。我们比较了冈比亚两个地区儿童疟疾和NTS感染的时间趋势。在沿海的Fajara，将1979至2005年间三个时间点的NTS感染发病率与疟疾阳性门诊患者厚血膜的百分比和一段时间内与疟疾有关的住院百分比进行了比较。在该国东部的Basse，比较了1989至2008年间三个时间点的NTS感染发病率与1992至2008年间四个时间点的疟疾寄生虫血症流行率。法贾拉地区NTS感染的估计发病率从每10万人年60例(1979-1984年)降至10例(2003-2005年)。法贾拉疑似疟疾患者的门诊寄生虫比例从1999年的33%下降到2007年的6%，与疟疾有关的住院患者比例从1999年的14.5%下降到2007年的5%。在Basse，NTS感染的估计发病率从1989年至1991年的每10万人年105例下降到2008年的29例，疟疾寄生虫血症的流行率从1992年的45%下降到2008年的10%。在研究期间，法贾拉和巴斯肺炎球菌菌血症的发病率没有下降。这些数据支持疟疾和NTS感染之间的联系。疟疾感染的减少可能与儿童侵袭性NTS感染率的降低有关。
Malaria is a risk factor for invasive non-typhoidal Salmonella (NTS) infection in children. In the last 10 years, indices of malaria infection in The Gambia have fallen substantially. We compared temporal trends of childhood malaria and NTS infection in two Gambian locations. In Fajara, on the coast, the incidence of NTS infection at three time points between 1979 and 2005 was compared to the percentage of malaria positive outpatient thick blood films and the percentage of admissions associated with malaria over time. In Basse, in the eastern part of the country, the incidence of NTS infection at three time points between 1989 and 2008 was compared to the prevalence of malaria parasitaemia at four time points between 1992 and 2008. The estimated incidence of NTS infection in Fajara fell from 60 (1979–1984) to 10 (2003–05) cases per 100,000 person years. The proportion of outpatients in Fajara with suspected malaria who were parasitaemic fell from 33% (1999) to 6% (2007) while the proportion of admissions associated with malaria fell from 14.5% (1999) to 5% (2007). In Basse, the estimated incidence of NTS infection fell from 105 (1989–1991) to 29 (2008) cases per 100,000 person years while the prevalence of malaria parasitaemia fell from 45% (1992) to 10% (2008). The incidence of pneumococcal bacteraemia in Fajara and Basse did not fall over the study period. These data support an association between malaria and NTS infection. Reductions in malaria infection may be associated with reduced rates of invasive childhood NTS infection.
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影响因子：
3
作者：
Satoguina, Judith;Walther, Brigitte;Walther, Michael
通讯作者：
Walther, Michael
影响因子：
168.9
作者：
Cutts, FT;Zaman, SMA;Adegbola, RA
通讯作者：
Adegbola, RA
影响因子：
168.9
作者：
ALONSO, PL;LINDSAY, SW;GREENWOOD, BM
通讯作者：
GREENWOOD, BM
影响因子：
158.5
作者：
Berkley, JA;Lowe, BS;Scott, JAG
通讯作者：
Scott, JAG
影响因子：
3.6
作者：
ODEMPSEY, TJD;MCARDLE, TF;GREENWOOD, BM
通讯作者：
GREENWOOD, BM