Adaptive proton therapy.
Adaptive proton therapy.
复制标题
适应性质子治疗。
DOI：
10.1088/1361-6560/ac344f
复制
发表时间：
2021-11-15
影响因子：
3.5
通讯作者：
Winey B
中科院分区：
文献类型：
--
作者：
Paganetti H;Botas P;Sharp GC;Winey B
放射疗法治疗通常基于单个图像集来规划，假设患者的解剖结构及其相对于递送系统的位置在治疗过程期间保持恒定。同样，处方剂量假定在整个治疗过程中具有恒定的生物学剂量-反应。然而，变化可以而且确实发生在多个时间尺度上。对于具有显著分次内运动的治疗部位，几何变化在数秒或数分钟内发生，而生物学考虑在数天或数周内发生变化。在中间时间尺度，每日治疗部分之间发生几何变化。适应性放射治疗用于考虑分次治疗过程中患者解剖结构的变化。虽然传统的适应已经完成离线重新规划的基础上，新的CT图像，在线治疗适应的基础上的板载成像已获得动力，近年来由于先进的成像技术与治疗输送系统相结合。适应性在质子治疗中尤其重要，其中由于质子束的剂量适形性和有限范围，患者解剖结构的微小变化可能导致显著的剂量扰动。本文综述了目前在线自适应质子治疗的最新进展，并指出了需要进一步研究的领域。
Radiation therapy treatments are typically planned based on a single image set, assuming that the patient’s anatomy and its position relative to the delivery system remains constant during the course of treatment. Similarly, the prescription dose assumes constant biological dose-response over the treatment course. However, variations can and do occur on multiple time scales. For treatment sites with significant intra-fractional motion, geometric changes happen over seconds or minutes, while biological considerations change over days or weeks. At an intermediate timescale, geometric changes occur between daily treatment fractions. Adaptive radiation therapy is applied to consider changes in patient anatomy during the course of fractionated treatment delivery. While traditionally adaptation has been done off-line with replanning based on new CT images, online treatment adaptation based on on-board imaging has gained momentum in recent years due to advanced imaging techniques combined with treatment delivery systems. Adaptation is particularly important in proton therapy where small changes in patient anatomy can lead to significant dose perturbations due to the dose conformality and finite range of proton beams. This review summarizes the current state-of-the-art of on-line adaptive proton therapy and identifies areas requiring further research.
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影响因子：
3.8
作者：
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通讯作者：
Wang J
影响因子：
3.8
作者：
Buti, Gregory;Souris, Kevin;Sterpin, Edmond
通讯作者：
Sterpin, Edmond
影响因子：
3.8
作者：
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通讯作者：
N端sslin, F
影响因子：
1.2
作者：
Boman, Eeva;Kapanen, Mika;Lahtela, Sirpa-Liisa
通讯作者：
Lahtela, Sirpa-Liisa
DOI：
10.1002/hed.23477
发表时间：
2014-11-01
影响因子：
2.9
作者：
Chen, Allen M.;Daly, Megan E.;Purdy, James A.
通讯作者：
Purdy, James A.