pRb, a local chromatin organizer with global possibilities.
pRb, a local chromatin organizer with global possibilities.
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DOI：
10.1007/s00412-009-0238-0
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发表时间：
2010-02
期刊：
影响因子：
1.6
通讯作者：
Dyson NJ
中科院分区：
文献类型：
--
作者：
Longworth MS;Dyson NJ
The retinoblastoma (Rb) family of proteins are well known for their tumor suppressor properties and for their ability to regulate transcription. The action of Rb-family members correlates with the appearance of repressive chromatin marks at promoter regions of genes encoding key regulators of cell proliferation. Recent studies raise the possibility that Rb family members do not simply act by controlling the activity of individual promoters but that they may also function by promoting the more general organization of chromatin. In several contexts, Rb-family members stimulate the compaction or condensation of chromatin and promote the formation of heterochromatin. In this review, we summarize studies that link pRb family members to the condensation or compaction of DNA.
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DOI：
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