Serum levels of FGF-21 are increased in coronary heart disease patients and are independently associated with adverse lipid profile.
Serum levels of FGF-21 are increased in coronary heart disease patients and are independently associated with adverse lipid profile.
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DOI：
10.1371/journal.pone.0015534
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发表时间：
2010-12-29
期刊：
影响因子：
3.7
通讯作者：
Li X
中科院分区：
文献类型：
--
作者：
Lin Z;Wu Z;Yin X;Liu Y;Yan X;Lin S;Xiao J;Wang X;Feng W;Li X
成纤维细胞生长因子21（FGF-21）是一种代谢调节剂，在动物模型中对葡萄糖稳态和脂质代谢具有多种有益作用。血浆FGF-21水平与冠心病的关系尚不清楚。本研究旨在探讨冠心病患者血清FGF-21水平与脂代谢的相关性。我们对血清FGF-21水平与冠心病患者（伴或不伴糖尿病和高血压）之间的关系进行了Logistic回归分析。本研究在两所大学医院的内分泌科和心血管科进行。参与者包括135名被诊断为冠心病的患者和61名对照组。检测血清FGF-21水平、空腹血糖、甘油三酯、载脂蛋白B100、HOMA-IR、胰岛素、总胆固醇、HDL-胆固醇、LDL-胆固醇和C-反应蛋白水平。冠心病组血清FGF-21水平明显高于对照组（P<0.0001）。冠心病合并糖尿病、高血压或两者兼有者血清FGF-21水平高于无合并症者。校正BMI、糖尿病和高血压后，血清FGF-21水平与甘油三酯、空腹血糖、载脂蛋白B100、胰岛素和HOMA-IR呈正相关，而与HDL-C和载脂蛋白A1呈负相关。Logistic回归分析显示FGF-21与甘油三酯和载脂蛋白A1独立相关。高水平的FGF-21与CHD患者的不良血脂相关。CHD患者血清FGF-21的反常升高可能表明对FGF-21的代偿反应或抵抗。
Fibroblast growth factor 21 (FGF-21) is a metabolic regulator with multiple beneficial effects on glucose homeostasis and lipid metabolism in animal models. The relationship between plasma levels of FGF-21 and coronary heart disease (CHD) in unknown. This study aimed to investigate the correlation of serum FGF-21 levels and lipid metabolism in the patients with coronary heart disease. We performed a logistic regression analysis of the relation between serum levels of FGF-21 and CHD patients with and without diabetes and hypertension. This study was conducted in the Departments of Endocrinology and Cardiovascular Diseases at two University Hospitals. Participants consisted of one hundred and thirty-five patients who have been diagnosed to have CHD and sixty-one control subjects. Serum FGF-21 level and levels of fasting blood glucose; triglyceride; apolipoprotein B100; HOMA-IR; insulin; total cholesterol; HDL-cholesterol; LDL-cholesterol; and C-reactive protein were measured. We found that median serum FGF-21 levels were significantly higher in CHD than that of control subjects (P<0.0001). Serum FGF-21 levels in CHD patients with diabetes, hypertension, or both were higher than that of patients without these comorbidities. Serum FGF-21 levels correlated positively with triglycerides, fasting blood glucose, apolipoprotein B100, insulin and HOMA-IR but negatively with HDL-C and apolipoprotein A1 after adjusting for BMI, diabetes and hypertension. Logistic regression analysis demonstrated that FGF-21 showed an independent association with triglyceride and apolipoprotein A1. High levels of FGF-21 are associated with adverse lipid profiles in CHD patients. The paradoxical increase of serum FGF-21 in CHD patients may indicate a compensatory response or resistance to FGF-21.
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影响因子：
4.3
作者：
Fu, Xiao-Bing;Li, Xiao-Kun;Sheng, Zhi-Yong
通讯作者：
Sheng, Zhi-Yong
DOI：
10.1073/pnas.95.10.5672
发表时间：
1998-05-12
影响因子：
11.1
作者：
Ortega, S;Ittmann, M;Basilico, C
通讯作者：
Basilico, C
正常受试者和新诊断 2 型糖尿病患者的循环 FGF-21 水平
影响因子：
1.8
作者：
Chen, W. -W.;Li, L.;Boden, G.
通讯作者：
Boden, G.
影响因子：
7.1
作者：
Kliewer, Steven A.;Mangelsdorf, David J.
通讯作者：
Mangelsdorf, David J.
DOI：
10.1038/nrd2792
发表时间：
2009-03
期刊：
Nature reviews. Drug discovery
影响因子：
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作者：
通讯作者：
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