Anomalous gray matter structural networks in patients with hepatitis B virus-related cirrhosis without overt hepatic encephalopathy.
Anomalous gray matter structural networks in patients with hepatitis B virus-related cirrhosis without overt hepatic encephalopathy.
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无明显肝性脑病的乙型肝炎病毒相关性肝硬化患者灰质结构网络异常。
DOI：
10.1371/journal.pone.0119339
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Wen G
中科院分区：
文献类型：
--
作者：
Lv XF;Liu K;Qiu YW;Cai PQ;Li J;Jiang GH;Deng YJ;Zhang XL;Wu PH;Xie CM;Wen G
越来越多的证据表明，在临床肝性脑病(OHE)发生之前，肝硬变可能影响患者不同脑区之间的连通性。然而，还没有研究在网络水平上对这些改变的连接进行结构重组的研究。本研究的主要目的是利用结构磁共振成像技术研究无OHE的乙肝病毒相关性肝硬变(HBVRC)患者体内结构网络的异常拓扑结构。应用图论分析方法，比较了28例无OHE的乙肝病毒感染者和30例年龄、性别、教育程度相匹配的健康对照组的灰质结构网络的整体和局部拓扑性质。基于灰质体积的测量，构建两组的结构相关网络。乙肝病毒-RC组的大脑网络在一系列网络密度的全球水平上显示出显著的集群系数和减少的小世界。在区域上，结节程度/中间度中心性改变的脑区主要观察到关联皮质(额叶和颞叶区域)(p<；0.001，未校正)，包括在颞下回结节程度显著降低(p<；0.001，未校正)。此外，与健康对照组相比，HBV-RC组表现出关联中心的丢失和非关联中心数量的增加。这项大规模灰质结构网络结构研究的结果表明，没有OHE的乙肝病毒相关性肺炎患者的拓扑组织效率降低。我们的发现从网络的角度提供了关于HBV-RC脑内神经生物重组机制的新见解。
Increasing evidence suggests that cirrhosis may affect the connectivity among different brain regions in patients before overt hepatic encephalopathy (OHE) occurs. However, there has been no study investigating the structural reorganization of these altered connections at the network level. The primary focus of this study was to investigate the abnormal topological organization of the structural network in patients with hepatitis B virus-related cirrhosis (HBV-RC) without OHE using structural MRI. Using graph theoretical analysis, we compared the global and regional topological properties of gray matter structural networks between 28 patients with HBV-RC without OHE and 30 age-, sex- and education-matched healthy controls. The structural correlation networks were constructed for the two groups based on measures of gray matter volume. The brain network of the HBV-RC group exhibited a significant decrease in the clustering coefficient and reduced small-worldness at the global level across a range of network densities. Regionally, brain areas with altered nodal degree/betweenness centrality were observed predominantly in association cortices (frontal and temporal regions) (p < 0.05, uncorrected), including a significantly decreased nodal degree in the inferior temporal gyrus (p < 0.001, uncorrected). Furthermore, the HBV-RC group exhibited a loss of association hubs and the emergence of an increased number of non-association hubs compared with the healthy controls. The results of this large-scale gray matter structural network study suggest reduced topological organization efficiency in patients with HBV-RC without OHE. Our findings provide new insight concerning the mechanisms of neurobiological reorganization in the HBV-RC brain from a network perspective.
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DOI：
10.1523/jneurosci.1929-08.2008
发表时间：
2008-09-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bassett DS;Bullmore E;Verchinski BA;Mattay VS;Weinberger DR;Meyer-Lindenberg A
通讯作者：
Meyer-Lindenberg A
影响因子：
34.7
作者：
Alexander-Bloch, Aaron;Giedd, Jay N.;Bullmore, Edward T.
通讯作者：
Bullmore, Edward T.
影响因子：
6.7
作者：
Lv, Xiao-Fei;Qiu, Ying-Wei;Zhang, Xue-Lin
通讯作者：
Zhang, Xue-Lin
影响因子：
3.7
作者：
Hsu TW;Wu CW;Cheng YF;Chen HL;Lu CH;Cho KH;Lin WC;Lin CP
通讯作者：
Lin CP
DOI：
10.1097/00042737-200409000-00012
发表时间：
2004-09-01
影响因子：
2.1
作者：
Burra, P;Senzolo, M;Dam, M
通讯作者：
Dam, M