Imaging structural co-variance between human brain regions.
Imaging structural co-variance between human brain regions.
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DOI：
10.1038/nrn3465
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发表时间：
2013-05
影响因子：
34.7
通讯作者：
Bullmore, Edward T.
中科院分区：
文献类型：
--
作者：
Alexander-Bloch, Aaron;Giedd, Jay N.;Bullmore, Edward T.
大脑结构以明显组织的方式之间有所不同。大脑区域的群落在形态学特性中共同变化。例如，一个区域的皮质厚度会影响结构和功能连接区域的厚度。这种结构共同变异的网络部分概括了健康个体的功能网络和神经退行性疾病中灰质丧失的焦点。该体系结构在遗传上是可遗传的，与行为和认知能力有关，并且在整个生命周期中都会系统地改变。这种结构协调的生物学含义仍然存在争议，但它似乎反映了大脑区域之间的发育协调或同步成熟。这篇综述讨论了当前对大脑结构共同变异的研究状态，其基本机制及其在理解各种神经和精神病条件方面的潜在价值。
Brain structure varies between people in a markedly organized fashion. Communities of brain regions co-vary in their morphological properties. For example, cortical thickness in one region influences the thickness of structurally and functionally connected regions. Such networks of structural co-variance partially recapitulate the functional networks of healthy individuals and the foci of grey matter loss in neurodegenerative disease. This architecture is genetically heritable, is associated with behavioural and cognitive abilities and is changed systematically across the lifespan. The biological meaning of this structural co-variance remains controversial, but it appears to reflect developmental coordination or synchronized maturation between areas of the brain. This Review discusses the state of current research into brain structural co-variance, its underlying mechanisms and its potential value in the understanding of various neurological and psychiatric conditions.
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DOI：
10.1523/jneurosci.1929-08.2008
发表时间：
2008-09-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bassett DS;Bullmore E;Verchinski BA;Mattay VS;Weinberger DR;Meyer-Lindenberg A
通讯作者：
Meyer-Lindenberg A
影响因子：
5.3
作者：
Achard, S;Salvador, R;Bullmore, ET
通讯作者：
Bullmore, ET
DOI：
10.1523/jneurosci.3554-12.2013
发表时间：
2013-02-13
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Alexander-Bloch A;Raznahan A;Bullmore E;Giedd J
通讯作者：
Giedd J
影响因子：
3.3
作者：
BERG, RL
通讯作者：
BERG, RL
影响因子：
2.6
作者：
Arnold, SJ
通讯作者：
Arnold, SJ