Cell physiology of the rat visceral yolk sac: a study of pinocytosis and lysosome function.
Cell physiology of the rat visceral yolk sac: a study of pinocytosis and lysosome function.
复制标题
大鼠内脏卵黄囊的细胞生理学：胞饮作用和溶酶体功能的研究。
DOI：
--
复制
发表时间：
1990
期刊：
影响因子：
--
通讯作者：
J. Lloyd
中科院分区：
文献类型：
--
作者：
J. Lloyd
大鼠内脏卵黄囊胞饮作用活跃。组织积累的大分子通常被输送到溶酶体，在那里它们要么积累（如果不能被溶酶体酶消化），要么被降解为其单体成分。卵黄囊细胞参与吸附胞饮作用，这导致优先摄取具有某些表面特征（例如疏水或阳离子结构域）的大分子。通过吸附胞饮作用进入卵黄囊的底物在某些情况下可以充当二价配体，通过“背负式”胞饮作用携带第二种物质。器官形成阶段大鼠胚胎对血浆蛋白的胞饮作用和溶酶体内消化发挥着重要的营养作用，提供了胚胎的高比例氨基酸需求。在妊娠的这个敏感阶段，抑制胞饮作用或溶酶体内蛋白水解作用的物质可能会诱发致畸作用。
The rat visceral yolk sac is active in pinocytosis. Macromolecules accumulated by the tissue are, in general, routed to the lysosomes, where they either accumulate (if non-digestible by the lysosomal enzymes) or are degraded to their monomeric components. The yolk sac cells engage in adsorptive pinocytosis, which leads to the preferential uptake of macromolecules bearing certain surface features, such as a hydrophobic or a cationic domain. Substrates that enter the yolk sac by adsorptive pinocytosis can in some cases act as bivalent ligands, carrying in a second substance by "piggy-back" pinocytosis. Pinocytosis and intralysosomal digestion of plasma proteins by the organogenesis-stage rat embryo play an important nutritional role, supplying a high proportion of the embryo's amino acid requirement. Teratogenic effects can be induced by substances that inhibit either pinocytosis or intralysosomal proteolysis at this sensitive stage of gestation.
卵黄囊抗血清对内脏卵黄囊功能影响的体外研究：一、胞饮作用和小分子转运。
DOI：
10.1002/tera.1420340313
发表时间：
1986
期刊：
Teratology
影响因子：
--
作者：
Lerman,S;Koszalka,TR;Jensen,M;Andrew,CL;Beckman,DA;Brent,RL
通讯作者：
Brent,RL