APT Weighted MRI as an Effective Imaging Protocol to Predict Clinical Outcome After Acute Ischemic Stroke.
APT Weighted MRI as an Effective Imaging Protocol to Predict Clinical Outcome After Acute Ischemic Stroke.
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APT 加权 MRI 作为预测急性缺血性中风后临床结果的有效成像方案
DOI：
10.3389/fneur.2018.00901
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发表时间：
2018
影响因子：
3.4
通讯作者：
Wu R
中科院分区：
文献类型：
--
作者：
Lin G;Zhuang C;Shen Z;Xiao G;Chen Y;Shen Y;Zong X;Wu R
探讨酰胺质子转移加权（APTW）磁共振成像（MRI）在评估急性缺血性脑卒中（AIS）患者住院时临床神经功能缺损和评估长期日常功能结局方面的能力。我们招募了 55 名 AIS 患者，这些患者在症状出现 24-48 小时内进行了脑部 MRI 检查，并随访了他们 90 天的改良 Rankin 量表 (mRS) 评分。对所有研究对象进行 APT 加权 MRI，定量测量急性缺血区 (APTWipsi) 和对侧 (APTWcont) 的 APTW 信号。计算急性缺血区与对侧APT信号的变化(ΔAPTW)。还获取了最大 APTW 信号 (APTWmax) 和最小 APTW 信号 (APTWmin) 以证明 APTW 信号异质性 (APTWmax−min)。此外，所有患者根据90天mRS评分分为2组（mRS评分<2的预后良好组和mRS评分≥2的预后不良组）。同时比较各组的ΔAPTW。我们发现 ΔAPTW 与美国国立卫生研究院卒中量表 (NIHSS) 评分 (R2 = 0.578, p < 0.001) 和 90 天 mRS 评分 (R2 = 0.55, p < 0.001) 具有良好的相关性。预后良好的患者与预后不良的患者之间ΔAPTW有显着性差异。另外，两组之间的 APTWmax−min 存在显着差异。这些结果表明，APT加权MRI可以作为评估AIS患者卒中严重程度和预后的有效工具，APTW信号异质性作为可能的生物标志物。
To explore the capability of the amide-proton-transfer weighted (APTW) magnetic resonance imaging (MRI) in the evaluation of clinical neurological deficit at the time of hospitalization and assessment of long-term daily functional outcome for patients with acute ischemic stroke (AIS). We recruited 55 AIS patients with brain MRI acquired within 24–48 h of symptom onset and followed up with their 90-day modified Rankin Scale (mRS) score. APT weighted MRI was performed for all the study subjects to measure APTW signal quantitatively in the acute ischemic area (APTWipsi) and the contralateral side (APTWcont). Change of the APT signal between the acute ischemic region and the contralateral side (ΔAPTW) was calculated. Maximum APTW signal (APTWmax) and minimal APTW signal (APTWmin) were also acquired to demonstrate APTW signals heterogeneity (APTWmax−min). In addition, all the patients were divided into 2 groups according to their 90-day mRS score (good prognosis group with mRS score <2 and poor prognosis group with mRS score ≥2). In the meantime, ΔAPTW of these groups was compared. We found that ΔAPTW was in good correlation with National Institutes of Health Stroke Scale (NIHSS) score (R2 = 0.578, p < 0.001) and 90-day mRS score (R2 = 0.55, p < 0.001). There was significant difference of ΔAPTW between patients with good prognosis and patients with poor prognosis. Plus, APTWmax−min was significantly different between two groups. These results suggested that APT weighted MRI could be used as an effective tool to assess the stroke severity and prognosis for patients with AIS, with APTW signal heterogeneity as a possible biomarker.
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影响因子：
6.3
作者：
Parsons, Mark W.;Christensen, Soren;Davis, Stephen M.
通讯作者：
Davis, Stephen M.
酰胺质子转移加权 MRI 评估脑缺血的演变
影响因子：
3.4
作者：
Song G;Li C;Luo X;Zhao X;Zhang S;Zhang Y;Jiang S;Wang X;Chen Y;Chen H;Gong T;Zhou J;Chen M
通讯作者：
Chen M
影响因子：
6.3
作者：
Sun, Phillip Zhe;Cheung, Jerry S.;Lo, Eng H.
通讯作者：
Lo, Eng H.
影响因子：
3.3
作者：
Heo HY;Zhang Y;Burton TM;Jiang S;Zhao Y;van Zijl PCM;Leigh R;Zhou J
通讯作者：
Zhou J
影响因子：
3.3
作者：
Chen, Jin-Hong;Sambol, Elliot B.;Singer, Samuel
通讯作者：
Singer, Samuel