Improving the detection sensitivity of pH-weighted amide proton transfer MRI in acute stroke patients using extrapolated semisolid magnetization transfer reference signals.
Improving the detection sensitivity of pH-weighted amide proton transfer MRI in acute stroke patients using extrapolated semisolid magnetization transfer reference signals.
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DOI：
10.1002/mrm.26799
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发表时间：
2017-09
影响因子：
3.3
通讯作者：
Zhou J
中科院分区：
文献类型：
--
作者：
Heo HY;Zhang Y;Burton TM;Jiang S;Zhao Y;van Zijl PCM;Leigh R;Zhou J
为了量化酸性缺血性病变中的适当作用，并评估扩散，灌注和pH之间的时空关系定义在急性中风患者中。
在3 t上扫描30例急性中风患者。使用外推的半固体磁化转移参考信号（EMR）技术测量酸性缺血性病变中的定量APT（APT＃）效应，并与常用的Mtrasym（3.5ppm）或APT-TEPEREDED-TEEMETED参数进行比较。 。
APT＃图像清晰的pH值定义了缺血性病变，而Mtrasym（3.5ppm）信号略有低血压。对比度（Apt＃vs.-1.45±0.40％，Mtrasym（3.5ppm），P <4.6×10-4）。观察到没有明显的扩散系数异常，并分配到缺血性酸中毒的pH值。
与传统的适合加权MRI相比，使用EMR方法的定量APT研究增强了对PH的合适MRI敏感性，从而使缺血性酸中毒的描述更加可靠。
To quantify APT effects in acidic ischemic lesions and assess the spatial-temporal relationship between diffusion, perfusion, and pH deficits in acute stroke patients. Thirty acute stroke patients were scanned at 3 T. Quantitative APT (APT#) effects in acidic ischemic lesions were measured using an extrapolated semisolid magnetization transfer reference signal (EMR) technique and compared with commonly used MTRasym(3.5ppm) or APT-weighted parameters. APT# images showed clear pH deficits in the ischemic lesion, whereas MTRasym(3.5ppm) signals were slightly hypointense. The APT# contrast between acidic ischemic lesions and normal tissue in acute stroke patients was more than 3 times larger than MTRasym(3.5ppm) contrast (−1.45 ± 0.40 % for APT# vs. −0.39 ± 0.52 % for MTRasym(3.5ppm), p < 4.6 × 10-4). Hypoperfused and acidic areas without an apparent diffusion coefficient abnormality were observed and assigned to an ischemic acidosis penumbra. Hypoperfused areas at normal pH were also observed and assigned to benign oligemia. Hyperintense APT signals were observed in a hemorrhage area in one case. The quantitative APT study using the EMR approach enhances APT MRI sensitivity to pH compared to conventional APT-weighted MRI, allowing more reliable delineation of an ischemic acidosis in the penumbra.
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