Switching of the Microglial Activation Phenotype Is a Possible Treatment for Depression Disorder.
Switching of the Microglial Activation Phenotype Is a Possible Treatment for Depression Disorder.
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小胶质细胞激活表型的转换是抑郁症的一种可能治疗方法
DOI：
10.3389/fncel.2018.00306
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发表时间：
2018
影响因子：
5.3
通讯作者：
You Z
中科院分区：
文献类型：
--
作者：
Zhang L;Zhang J;You Z
重度抑郁症（MDD）是一种常见的情绪认知障碍，严重影响人们的身心健康和生活质量。由于其临床和病因的异质性，支持MDD的分子机制是复杂的，它们尚未完全了解。此外，传统的药物治疗效果并不理想。然而，死后和动物研究表明，过度激活的小胶质细胞可以抑制海马体的神经发生并诱导抑郁样行为。尽管如此，小胶质细胞调节神经再生和决定抑郁样行为的分子机制仍不清楚。作为中枢神经系统（CNS）的免疫细胞，小胶质细胞可以通过M1和M2亚型影响神经发生，这些亚型可能促进抑郁样行为。小胶质细胞可分为四种主要状态或表型。应激状态下，小胶质细胞被诱导为M1型，释放炎症因子，引起神经炎症反应。炎症消退后，小胶质细胞转变为在神经保护中起作用的活化M2表型。这些活化的M2亚型包括M2a、M2b和M2c，它们在中枢神经系统中的功能不同。本文主要介绍小胶质细胞与重度抑郁症的关系。重要的是，本文阐明了小胶质细胞调节炎症和神经发生以改善重度抑郁症的合理机制。这为今后重度抑郁症的治疗提供了可靠的依据。
Major depressive disorder (MDD) is a common emotional cognitive disorder that seriously affects people’s physical and mental health and their quality of life. Due to its clinical and etiological heterogeneity, the molecular mechanisms underpinning MDD are complex and they are not fully understood. In addition, the effects of traditional drug therapy are not ideal. However, postmortem and animal studies have shown that overactivated microglia can inhibit neurogenesis in the hippocampus and induce depressive-like behaviors. Nonetheless, the molecular mechanisms by which microglia regulate nerve regeneration and determine depressive-like behaviors remain unclear. As the immune cells of the central nervous system (CNS), microglia could influence neurogenesis through the M1 and M2 subtypes, and these may promote depressive-like behaviors. Microglia may be divided into four main states or phenotypes. Under stress, microglial cells are induced into the M1 type, releasing inflammatory factors and causing neuroinflammatory responses. After the inflammation fades away, microglia shift into the alternative activated M2 phenotypes that play a role in neuroprotection. These activated M2 subtypes consist of M2a, M2b and M2c and their functions are different in the CNS. In this article, we mainly introduce the relationship between microglia and MDD. Importantly, this article elucidates a plausible mechanism by which microglia regulate inflammation and neurogenesis in ameliorating MDD. This could provide a reliable basis for the treatment of MDD in the future.
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影响因子：
9.3
作者：
Cherry JD;Olschowka JA;O'Banion MK
通讯作者：
O'Banion MK
影响因子：
11.2
作者：
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通讯作者：
Weiner, Howard L.
影响因子：
10.6
作者：
Dowlati, Yekta;Herrmann, Nathan;Lanctot, Krista L.
通讯作者：
Lanctot, Krista L.
影响因子：
3
作者：
Bilbo SD;Schwarz JM
通讯作者：
Schwarz JM
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DOI：
10.3390/molecules23092371
发表时间：
2018-09-17
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Feng S;Zou L;Wang H;He R;Liu K;Zhu H
通讯作者：
Zhu H