Age-Related Changes in Diurnal Rhythms and Levels of Gonadotropins, Testosterone, and Inhibin B in Male Rhesus Monkeys (Macaca mulatta)1
Age-Related Changes in Diurnal Rhythms and Levels of Gonadotropins, Testosterone, and Inhibin B in Male Rhesus Monkeys (Macaca mulatta)1
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雄性恒河猴 (Macaca mulatta)1 昼夜节律以及促性腺激素、睾酮和抑制素 B 水平与年龄相关的变化1
DOI：
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发表时间：
2008
影响因子：
3.6
通讯作者：
S. Ramaswamy
中科院分区：
文献类型：
--
作者：
S. Schlatt;C. R. Pohl;J. Ehmcke;S. Ramaswamy
摘要在早晨低血清水平的猴子中，Tehran显示了昼夜节律。这种下降依赖于LH脉冲频率的降低。抑制素B无昼夜变化。在老年男性中，睾丸激素的昼夜节律变钝，而睾酮水平下降。在这里，我们探讨是否老化在恒河猴中产生类似的影响。我们收集了血液样本组的年轻（6-9岁）和老年（12-16岁）雄性恒河猴在20分钟的时间间隔为24小时的远程采样下，通过静脉导管。我们通过RIA测定血浆睾酮、FSH和LH水平的每时每刻的变化，通过ELISA测定血浆白蛋白B的变化。我们发现两组的睾丸激素的昼夜模式显着。老年猴子的睾酮昼夜节律增强。在中午时分，睾酮水平和脉搏频率明显低于年轻猴子。LH脉冲频率降低似乎是老年猴中午睾酮下降的原因，而LH和睾酮脉冲频率在相应的时间点在年轻猴中没有变化。老年猴子在早晨和中午表现出长时间的LH脉冲静止。老年猴的抑制素B和FSH水平普遍低于年轻组，但抑制素B和FSH均未表现出昼夜节律。我们得出结论，从这些数据，老年恒河猴有一个更突出的LH和睾酮的昼夜节律，导致下丘脑-垂体-性腺轴的延长中午期的静止。
Abstract Testosterone shows circadian rhythms in monkeys with low serum levels in the morning hours. The decline relies on a diminished frequency of LH pulses. Inhibin B shows no diurnal patterns. In elderly men, the diurnal rhythm of testosterone is blunted and inhibin levels fall. Here we explore whether aging exerts similar effects in the rhesus monkey. We collected blood samples from groups of young (6–9 yr) and old (12–16 yr) male rhesus monkeys at 20-min intervals for a period of 24 h under remote sampling via a venous catheter. We determined moment-to-moment changes in plasma levels of testosterone, FSH, and LH by RIA, and of inhibin B by ELISA. We found significant diurnal patterns of testosterone in both groups. The circadian rhythm in testosterone was enhanced in older monkeys. Testosterone levels and pulse frequencies dropped significantly below those of young monkeys during midday hours. Diminished pulse frequency of LH appeared to be responsible for the midday testosterone decrease in old monkeys, while LH and testosterone pulse frequency did not change in young monkeys at corresponding time points. Old monkeys showed extended periods of LH-pulse quiescence in the morning and midday hours. Inhibin B and FSH levels were generally lower in old monkeys compared with the young group, but neither inhibin B nor FSH showed circadian rhythms. We conclude from these data that old rhesus monkeys have a more prominent circadian rhythm of LH and testosterone resulting from an extended midday period of quiescence in the hypothalamus-pituitary-gonadal axis.
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来自恒河猴（Macaca mulatta）的证据表明，睾丸黄体生成素分泌的负反馈控制是通过下丘脑促性腺激素释放激素脉冲频率的减慢介导的。
影响因子：
4.8
作者：
Plant,TM;Dubey,AK
通讯作者：
Dubey,AK
影响因子：
4.8
作者：
Keenan, Daniel M.;Takahashi, Paul Y.;Veldhuis, Johannes D.
通讯作者：
Veldhuis, Johannes D.
DOI：
10.1210/jcem.86.2.7219
发表时间：
2001-02
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
S. Harman;E. Metter;J. Tobin;J. Pearson;M. Blackman
通讯作者：
S. Harman;E. Metter;J. Tobin;J. Pearson;M. Blackman
男性下丘脑-垂体-性腺轴的操作特征：睾酮和卵泡刺激素的脉冲式释放及其与黄体生成素的时间耦合。
DOI：
10.1210/jcem-65-5-929
发表时间：
1987
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Veldhuis,JD;King,JC;Urban,RJ;Rogol,AD;Evans,WS;Kolp,LA;Johnson,ML
通讯作者：
Johnson,ML
年轻和老年男性血清免疫反应性抑制素的昼夜节律。
DOI：
10.1093/geronj/46.5.m181
发表时间：
1991
期刊：
Journal of gerontology
影响因子：
--
作者：
Tenover,JS;Bremner,WJ
通讯作者：
Bremner,WJ