The association between pro-inflammatory cytokines, regional cerebral metabolism, and cognitive complaints following adjuvant chemotherapy for breast cancer.
The association between pro-inflammatory cytokines, regional cerebral metabolism, and cognitive complaints following adjuvant chemotherapy for breast cancer.
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DOI：
10.1007/s11682-013-9243-2
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发表时间：
2013-12
影响因子：
3.2
通讯作者：
Silverman, D. H. S.
中科院分区：
文献类型：
--
作者：
Pomykala, K. L.;Ganz, P. A.;Bower, J. E.;Kwan, L.;Castellon, S. A.;Mallam, S.;Cheng, I.;Ahn, R.;Breen, E. C.;Irwin, M. R.;Silverman, D. H. S.
关键词：
To examine relationships following adjuvant chemotherapy between circulating proinflammatory cytokines, regional cerebral metabolism, and cognitive complaints in early stage breast cancer patients. 33 breast cancer patients who had completed initial treatment (surgery, ± radiation, 23 chemotherapy, 10 no chemotherapy) obtained resting (18)F-FDG PET/CT brain imaging at baseline and one year later. Pro-inflammatory cytokine markers (IL-1ra, sTNF-RII, CRP, and IL-6) and cognitive complaints were also assessed at both time points. At baseline, consistent correlations were seen between the left medial frontal and right inferior lateral anterior temporal cortices and inflammatory markers within the chemotherapy group, and not in the group who did not receive chemotherapy. After one year, correlations persisted in the medial frontal cortex and the temporal cortex, the latter shifting superiorly. Both of these regional correlations demonstrated the highest levels of significance when looking across the one year time frame (IL-1ra: peak voxel p<0.0005; cluster size p<0.0005, p=0.001 after correction (medial prefrontal), p<0.0005; cluster size p=0.001, p=0.029 corr. (anterior temporal), sTNF-RII: p<0.0005; cluster size p=0.001, p=0.040 corr. (medial prefrontal)). Positive correlations were also seen within the chemotherapy group between baseline memory complaints and the medial frontal (p<0.0005; cluster size p<0.0005, p<0.0005 corr.) and anterior temporal (p<0.0005; cluster size p<0.0005, p=0.002 corr.) cortices at baseline and one year later. Metabolism in the medial prefrontal cortex and anterior temporal cortex was found to correlate with both memory complaints and cytokine marker levels in chemotherapy patients.
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影响因子：
45.3
作者：
Ahles, Tim A.;Saykin, Andrew J.;Kaufman, Peter A.
通讯作者：
Kaufman, Peter A.
影响因子：
45.3
作者：
Bower, Julienne E.;Ganz, Patricia A.;Cole, Steven W.
通讯作者：
Cole, Steven W.
影响因子：
3.1
作者：
Jansen, Catherine E.;Cooper, Bruce A.;Miaskowski, Christine A.
通讯作者：
Miaskowski, Christine A.
DOI：
10.2967/jnumed.111.097014
发表时间：
2012-04
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Hannestad J;Subramanyam K;Dellagioia N;Planeta-Wilson B;Weinzimmer D;Pittman B;Carson RE
通讯作者：
Carson RE
影响因子：
45.3
作者：
Ahles, TA;Saykin, AJ;Silberfarb, PM
通讯作者：
Silberfarb, PM