Targeting Ubiquitin-Specific Protease 7 (USP7) in Cancer: A New Insight to Overcome Drug Resistance.
Targeting Ubiquitin-Specific Protease 7 (USP7) in Cancer: A New Insight to Overcome Drug Resistance.
复制标题
靶向癌症中的泛素特异性蛋白酶 7 (USP7)：克服耐药性的新见解
DOI：
10.3389/fphar.2021.648491
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发表时间：
2021
影响因子：
5.6
通讯作者：
Yang X
中科院分区：
文献类型：
--
作者：
Lu J;Zhao H;Yu C;Kang Y;Yang X
化疗耐药性是肿瘤治疗失败的主要原因之一。因此，有必要进一步研究和了解肿瘤耐药的潜在机制，以设计和开发新的抗肿瘤药物。翻译后修饰是蛋白质在生理和病理条件下发挥功能的关键，其中泛素化修饰是最常见的一种。由泛素-蛋白酶体系统介导的蛋白质降解过程是泛素化修饰最著名的功能。然而，泛素化也参与了许多其他生物学过程的调节，如蛋白质运输和蛋白质-蛋白质相互作用。一组称为去泛素化酶的蛋白质可以水解异肽键并分解泛素-蛋白质结合物，从而防止底物蛋白质降解或其他结果。泛素特异性蛋白酶7（USP 7）是研究最广泛的去泛素化酶之一。USP 7在多种恶性肿瘤中表现出高表达特征，并且USP 7表达增加通常指示肿瘤预后不良，这表明USP 7是肿瘤预后的标志物和抗肿瘤治疗的潜在药物靶点。本文首先对USP 7的结构和功能进行了综述。本文综述了肿瘤细胞对抗肿瘤治疗产生耐药性的机制，为以USP 7为靶点克服耐药性提供了理论支持，并为USP 7抑制剂的设计和开发提供了一些启示。
Chemoresistance is one of the leading causes for the failure of tumor treatment. Hence, it is necessary to study further and understand the potential mechanisms of tumor resistance to design and develop novel anti-tumor drugs. Post-translational modifications are critical for proteins’ function under physiological and pathological conditions, among which ubiquitination is the most common one. The protein degradation process mediated by the ubiquitin-proteasome system is the most well-known function of ubiquitination modification. However, ubiquitination also participates in the regulation of many other biological processes, such as protein trafficking and protein-protein interaction. A group of proteins named deubiquitinases can hydrolyze the isopeptide bond and disassemble the ubiquitin-protein conjugates, thus preventing substrate proteins form degradation or other outcomes. Ubiquitin-specific protease 7 (USP7) is one of the most extensively studied deubiquitinases. USP7 exhibits a high expression signature in various malignant tumors, and increased USP7 expression often indicates the poor tumor prognosis, suggesting that USP7 is a marker of tumor prognosis and a potential drug target for anti-tumor therapy. In this review, we first discussed the structure and function of USP7. Further, we summarized the underlying mechanisms by which tumor cells develop resistance to anti-tumor therapies, provided theoretical support for targeting USP7 to overcome drug resistance, and some inspiration for the design and development of USP7 inhibitors.
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影响因子：
13.6
作者：
Dai C;Gu W
通讯作者：
Gu W
影响因子：
16
作者：
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通讯作者：
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新型USP7抑制剂噻唑衍生物的合成及生物学评价
影响因子：
2.7
作者：
Chen, Chao;Song, Jiemei;Wen, Xiaoan
通讯作者：
Wen, Xiaoan
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影响因子：
6.7
作者：
Li, Minglei;Liu, Shengjie;Wen, Xiaoan
通讯作者：
Wen, Xiaoan
影响因子：
5.7
作者：
Colland, Frederic;Formstecher, Etienne;Daviet, Laurent
通讯作者：
Daviet, Laurent