Qi-Regulating and Blood Circulation-Promoting Therapy Improves Health Status of Stable Angina Pectoris Patients with Depressive Symptoms.
Qi-Regulating and Blood Circulation-Promoting Therapy Improves Health Status of Stable Angina Pectoris Patients with Depressive Symptoms.
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理气活血疗法改善伴有抑郁症状的稳定型心绞痛患者健康状况
DOI：
10.1155/2021/7319417
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Liu XH
中科院分区：
文献类型：
--
作者：
Wang XR;Song DD;Tao TQ;He T;Wu XD;Li XM;Liu XH
抑郁症在冠心病（CHD）患者中非常普遍，严重影响患者的生活质量。然而，大多数精神药物都有潜在副作用的警告。因此，迫切需要更安全有效的替代品。冠心病心绞痛在中医上被认为是“胸闷心痛证”，其主要证型为气滞血瘀。调气活血疗法在冠心病患者中越来越显示出独特的优势。本研究探讨调气活血的代表性方血附逐瘀汤对心绞痛合并抑郁症状患者的疗效。在基线和12周随访研究中对30例稳定型心绞痛患者的抑郁症状进行分层。分层分析后，采用相关问卷量表对心绞痛特异性健康状况和中医“胸闷心痛综合征”进行自我报告评价。我们测量了血清中血清素、脑源性神经营养因子和ATP的浓度，它们与抑郁症的发展有关。我们发现血府逐瘀颗粒治疗12周后可显著改善患者心绞痛特异性健康状况；具体来说，它对有抑郁症状的患者有较好的疗效。血瘀逐瘀颗粒对抑郁症状患者的胸闷、心痛综合征也有显著改善作用（疗效指数为61.24%，与基线比较P < 0.05）。有趣的是，研究发现血府竹玉颗粒对抑郁症状患者ATP水平的改善更敏感，提示血府竹玉颗粒对抑郁症状患者血清ATP水平的改善可能是其疗效更好的原因。本研究结果为血瘀逐瘀颗粒通过调气活血改善心绞痛特异性健康状况提供了前瞻性证据。本试验注册号为ChiCTR-IOR-15006989。
Depressive symptoms have been found to be highly prevalent among patients with coronary heart disease (CHD) and seriously affect the patients' quality of life. However, most psychotropic drugs have warnings about potential side effects. Accordingly, safer effective alternatives are urgently demanded. Angina pectoris of CHD is considered as “chest stuffiness and heartache syndrome” in traditional Chinese medicine, with the major syndrome type named Qi stagnation and blood stasis. Qi-regulating and blood circulation-promoting therapy has increasingly shown unique advantages in CHD patients. This study investigated the efficacy of Xuefu Zhuyu decoction, a representative prescription of Qi-regulating and blood circulation-promoting therapy, on angina pectoris patients with depressive symptoms. Depressive symptoms were stratified at baseline in 30 patients with stable angina pectoris who participated in both baseline and 12-week follow-up studies. After performing a stratified analysis, the angina pectoris-specific health status and traditional Chinese medicine “chest stuffiness and heartache syndrome” were evaluated by self-reports using the associated questionnaire scales, respectively. We measured serum concentrations of serotonin, brain-derived neurotrophic factor, and ATP, which are associated with the development of depression. We found that the Xuefu Zhuyu granule significantly improved the angina pectoris-specific health status in patients after 12 weeks of treatment; specifically, it had a better curative effect on patients with depressive symptoms. Xuefu Zhuyu granule also significantly improved the chest stuffiness and heartache syndrome in patients with depressive symptoms (efficacy index is 61.24%, P < 0.05 versus baseline). Interestingly, Xuefu Zhuyu granule has been found to be more susceptible to improving ATP levels in patients with depressive symptoms, indicating that the improvement in serum ATP levels might account for the better efficacy of Xuefu Zhuyu granule in patients with depressive symptoms. Our data provide prospective evidence that Xuefu Zhuyu granule improves angina pectoris-specific health status through regulating Qi and promoting blood circulation. This trial is registered with ChiCTR-IOR-15006989.
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作者：
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作者：
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DOI：
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