Localization and trafficking of aquaporin 2 in the kidney.
Localization and trafficking of aquaporin 2 in the kidney.
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DOI：
10.1007/s00418-008-0457-0
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发表时间：
2008-08
影响因子：
2.3
通讯作者：
Hasegawa, Takahiro
中科院分区：
文献类型：
--
作者：
Takata, Kuniaki;Matsuzaki, Toshiyuki;Tajika, Yuki;Ablimit, Abduxukur;Hasegawa, Takahiro
水通道蛋白(Aquaporins，AQPs)是一种膜蛋白，在水和小分子溶质的跨细胞膜转运中起作用。水通道蛋白在体内发挥着多种作用，如尿液形成、防止上皮细胞脱水、血脑屏障中的水处理、分泌、感觉系统的调节、细胞运动和转移、细胞连接的形成和脂肪代谢。肾脏在体内水分动态平衡中起着核心作用。至少表达了7种亚型，即AQP1、AQP2、AQP3、AQP4、AQP6、AQP7和AQP11。其中，抗利尿激素(ADH)调节的水通道AQP2在水重吸收中起着关键作用。AQP2在连接小管和集合管的主细胞中表达，在基础状态下储存在Rab11阳性的储存囊中。在ADH刺激下，AQP2被转移到顶端质膜，在那里它服务于水的流入。转位过程是通过蛋白激酶A对AQP2的磷酸化来调节的。一旦刺激终止，AQP2就被回收到早期的内吞体内，然后转移回RAB11阳性的储存室。一些AQP2通过多囊泡体以外体的形式分泌到尿液中。肌动蛋白在AQP2的细胞内转运中起重要作用。最近的发现揭示了控制AQP2贩运的分子基础。
Aquaporins (AQPs) are membrane proteins serving in the transfer of water and small solutes across cellular membranes. AQPs play a variety of roles in the body such as urine formation, prevention from dehydration in covering epithelia, water handling in the blood–brain barrier, secretion, conditioning of the sensory system, cell motility and metastasis, formation of cell junctions, and fat metabolism. The kidney plays a central role in water homeostasis in the body. At least seven isoforms, namely AQP1, AQP2, AQP3, AQP4, AQP6, AQP7, and AQP11, are expressed. Among them, AQP2, the anti-diuretic hormone (ADH)-regulated water channel, plays a critical role in water reabsorption. AQP2 is expressed in principal cells of connecting tubules and collecting ducts, where it is stored in Rab11-positive storage vesicles in the basal state. Upon ADH stimulation, AQP2 is translocated to the apical plasma membrane, where it serves in the influx of water. The translocation process is regulated through the phosphorylation of AQP2 by protein kinase A. As soon as the stimulation is terminated, AQP2 is retrieved to early endosomes, and then transferred back to the Rab 11-positive storage compartment. Some AQP2 is secreted via multivesicular bodies into the urine as exosomes. Actin plays an important role in the intracellular trafficking of AQP2. Recent findings have shed light on the molecular basis that controls the trafficking of AQP2.
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影响因子：
7
作者：
Barile, M;Pisitkun, T;Knepper, MA
通讯作者：
Knepper, MA
DOI：
10.1073/pnas.0712338105
发表时间：
2008-02-26
影响因子：
11.1
作者：
Fenton, Robert A.;Moeller, Hanne B.;Knepper, Mark A.
通讯作者：
Knepper, Mark A.
影响因子：
4.8
作者：
Hales, CM;Vaerman, JP;Goldenring, JR
通讯作者：
Goldenring, JR
影响因子：
4.8
作者：
Chou, CL;Yip, KP;Knepper, MA
通讯作者：
Knepper, MA
影响因子：
--
作者：
Ablimit, A;Matsuzaki, T;Takata, K
通讯作者：
Takata, K