A clinicopathologic study of optic neuropathies associated with intracranial mass lesions with quantification of remaining axons.

A clinicopathologic study of optic neuropathies associated with intracranial mass lesions with quantification of remaining axons.
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与颅内肿块病变相关的视神经病变的临床病理学研究以及剩余轴突的量化。

DOI:
10.1016/s0002-9394(14)78297-2
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发表时间:
1983
影响因子:
4.2
通讯作者:
Miller,NR
Miller,NR
中科院分区:
医学1区
文献类型:
--
作者:
Levin,PS;Newman,SA;Quigley,HA;Miller,NR

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我们检查了三名颅内肿块病变损害前视通路的患者,并在患者死亡后对这种损害进行了组织学研究。对六条视神经中存活轴突数量的估计通常显示,在地球仪后面的横截面中,颞部萎缩最严重。在地球仪的更后方,几条神经的中央出现最大的萎缩。这种损伤模式可能是由于黄斑轴突对沿着前视觉通路的损伤的特别脆弱性。视盘苍白存在于两只眼睛中,剩下的轴突少于正常数量的40%,而一个视盘似乎是正常的,70%的轴突完整。在两名患者中观察到传入性瞳孔缺损,这两名患者在对侧视神经中的剩余轴突是缺损侧神经中的两到三倍。
We examined three patients with intracranial mass lesions that damaged the anterior visual pathway and studied this damage histologically after the patients died. Estimation of the number of surviving axons in the six optic nerves generally showed the greatest atrophy to be in the temporal sector in cross sections immediately behind the globe. More posterior to the globe, atrophy appeared greatest in the center of several nerves. This pattern of damage may result from particular vulnerability of macular axons to damage along the anterior visual pathway. Optic disk pallor was present in two eyes that had less than 40% of the normal number of axons remaining, while one optic disk appeared to be normal with 70% of the axons intact. Afferent pupillary defects were observed in two patients who had two to three times as many remaining axons in the contralateral optic nerve as in the nerve on the side of the defect.
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影响因子: 4.3
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