Prognostic significance of tumor immune microenvironment and immunotherapy: Novel insights and future perspectives in gastric cancer.
Prognostic significance of tumor immune microenvironment and immunotherapy: Novel insights and future perspectives in gastric cancer.
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肿瘤免疫微环境和免疫治疗的预后意义：胃癌的新见解和未来前景。
DOI：
10.3748/wjg.v24.i32.3583
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发表时间：
2018-08-28
影响因子：
4.3
通讯作者：
Goldiș A
中科院分区：
文献类型：
--
作者：
Lazăr DC;Avram MF;Romoșan I;Cornianu M;Tăban S;Goldiș A
尽管胃癌的发病率有所下降，新型生物制剂和综合治疗策略的发展，但胃癌的预后仍然很差。最近，现代免疫疗法的引入，特别是使用免疫检查点抑制剂，导致许多癌症的预后改善。在胃癌患者的治疗中，免疫疗法的使用也与可控的不良事件和有希望的结果相关，特别是在大量预处理的患者中。这些数据加速了一些检查点抑制剂在这种情况下的批准。了解宿主免疫微环境与肿瘤之间的复杂关系，以及导致癌症发生和进展的免疫逃逸现象，将有助于识别预后免疫标志物。此外，这种理解将导致发现阻断肿瘤免疫抑制信号的新机制和通过靶向和调节不同的免疫细胞亚群来刺激局部免疫反应的途径。由于胃癌的分子异质性与不同的临床生物学参数、免疫标志物表达和预后相关，新的免疫治疗算法应该是个性化的，并针对选定的胃肿瘤亚群，这已经被证明可以引起最佳的临床反应。未来胃癌治疗的前景包括有针对性的双重免疫治疗或与其他靶向药物联合免疫治疗，具有协同抗肿瘤作用。
Despite a decrease in gastric cancer incidence, the development of novel biologic agents and combined therapeutic strategies, the prognosis of gastric cancer remains poor. Recently, the introduction of modern immunotherapy, especially using immune checkpoint inhibitors, led to an improved prognosis in many cancers. The use of immunotherapy was also associated with manageable adverse event profiles and promising results in the treatment of patients with gastric cancer, especially in heavily pretreated patients. These data have led to an accelerated approval of some checkpoint inhibitors in this setting. Understanding the complex relationship between the host immune microenvironment and tumor and the immune escape phenomenon leading to cancer occurrence and progression will subsequently lead to the identification of prognostic immune markers. Furthermore, this understanding will result in the discovery of both new mechanisms for blocking tumor immunosuppressive signals and pathways to stimulate the local immune response by targeting and modulating different subsets of immune cells. Due to the molecular heterogeneity of gastric cancers associated with different clinico-biologic parameters, immune markers expression and prognosis, novel immunotherapy algorithms should be personalized and addressed to selected subsets of gastric tumors, which have been proven to elicit the best clinical responses. Future perspectives in the treatment of gastric cancer include tailored dual immunotherapies or a combination of immunotherapy with other targeted agents with synergistic antitumor effects.
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影响因子：
4.4
作者：
Bourquin, Carole;von der Borch, Philip;Endres, Stefan
通讯作者：
Endres, Stefan
影响因子：
4.4
作者：
Almand, B;Clark, JI;Gabrilovich, DI
通讯作者：
Gabrilovich, DI
影响因子：
6.2
作者：
Ajani, JA;Hecht, JR;Michaeli, D
通讯作者：
Michaeli, D
DOI：
10.1056/nejmoa1200694
发表时间：
2012-06-28
期刊：
The New England journal of medicine
影响因子：
--
作者：
Brahmer JR;Tykodi SS;Chow LQ;Hwu WJ;Topalian SL;Hwu P;Drake CG;Camacho LH;Kauh J;Odunsi K;Pitot HC;Hamid O;Bhatia S;Martins R;Eaton K;Chen S;Salay TM;Alaparthy S;Grosso JF;Korman AJ;Parker SM;Agrawal S;Goldberg SM;Pardoll DM;Gupta A;Wigginton JM
通讯作者：
Wigginton JM
影响因子：
20.3
作者：
Benchetrit, F;Ciree, A;Tartour, E
通讯作者：
Tartour, E