Effects of chronic treatment with bupropion on self-administration of nicotine + cocaine mixtures in nonhuman primates.
Effects of chronic treatment with bupropion on self-administration of nicotine + cocaine mixtures in nonhuman primates.
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DOI：
10.1037/pha0000333
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发表时间：
2020-10
影响因子：
2.3
通讯作者：
Kohut SJ
中科院分区：
文献类型：
--
作者：
de Moura FB;Barkin CE;Blough BE;Carroll FI;Mello NK;Kohut SJ
与长期使用尼古丁相关的慢性健康问题是美国可预防死亡的主要原因。可卡因使用障碍患者的烟草制品使用量是一般人群的 3-4 倍。这可能反映了尼古丁增强可卡因增强作用的倾向。然而，尼古丁的作用机制与可卡因不同，这对开发用于管理尼古丁+可卡因多种药物滥用的药物治疗干预措施提出了重大挑战。安非他酮是 FDA 批准的戒烟辅助剂，对单胺转运蛋白和烟碱受体均具有药理作用，表明它可能有效减少尼古丁和可卡因的共同滥用。在这里，恒河猴 (n = 4) 对食物颗粒做出反应，并在使用盐水或安非他酮（1.0 和 1.8 毫克/千克/小时）连续治疗 7-10 天期间，按照二阶 FR2(VR16:S) 强化方案分别静脉注射尼古丁、可卡因或尼古丁 + 可卡因混合物。结果表明，安非他酮治疗剂量依赖性地减少了尼古丁与低剂量可卡因（0.0032 mg/kg/注射）联合的自我给药；然而，当混合物中可卡因的剂量较高（即 0.01 毫克/千克/注射）时，安非他酮仅在一部分受试者中减弱自我给药。安非他酮的有效剂量增加了对单独可卡因、单独尼古丁和盐水注射的反应，并显着增加了日常活动的测量。安非他酮在减少可卡因+尼古丁自我给药所需剂量下的明显兴奋剂样作用并不支持其临床用于管理尼古丁+可卡因多种药物滥用。
Chronic health problems associated with long-term nicotine use are the leading cause of preventable death in the United States. The use of tobacco products is 3–4 times greater among individuals with cocaine use disorder than that observed in the general population. This may reflect the propensity of nicotine to augment the reinforcing effects of cocaine. However, the mechanism of action of nicotine differs from that of cocaine, which presents a significant challenge for the development of pharmacotherapeutic interventions for the management of nicotine + cocaine polydrug abuse. Bupropion, an FDA-approved smoking cessation aid, has pharmacological actions at both monoamine transporters and nicotinic receptors, suggesting that it may be effective at decreasing nicotine + cocaine co-abuse. Here, rhesus monkeys (n=4) responded for food pellets and, separately, intravenous injections of nicotine, cocaine, or nicotine + cocaine mixtures under a second-order FR2(VR16:S) schedule of reinforcement during 7–10-day continuous treatment with saline or bupropion (1.0 and 1.8 mg/kg/hr). Results show that bupropion treatment dose-dependently decreased self-administration of nicotine combined with a low dose of cocaine (0.0032 mg/kg/inj); however, when the dose of cocaine in the mixture was higher (i.e., 0.01 mg/kg/inj), bupropion attenuated self-administration in only a subset of subjects. The effective dosage of bupropion increased responding for cocaine alone, nicotine alone, and for saline injections, and significantly increased measures of daily activity. The apparent stimulant-like effects of bupropion at the dosage required to decrease cocaine + nicotine self-administration does not support its clinical use for the management of nicotine + cocaine polydrug abuse.
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DOI：
10.1017/s1461145712000661
发表时间：
2013-03
期刊：
The international journal of neuropsychopharmacology
影响因子：
--
作者：
Bergman J;Roof RA;Furman CA;Conroy JL;Mello NK;Sibley DR;Skolnick P
通讯作者：
Skolnick P
哺乳动物烟碱乙酰胆碱受体：从结构到功能。
影响因子：
33.6
作者：
Albuquerque EX;Pereira EF;Alkondon M;Rogers SW
通讯作者：
Rogers SW
影响因子：
3.4
作者：
Desai, RI;Barber, DJ;Terry, P
通讯作者：
Terry, P
影响因子：
3.4
作者：
HORGER, BA;GILES, MK;SCHENK, S
通讯作者：
SCHENK, S
影响因子：
4.7
作者：
Grady, Sharon R.;Drenan, Ryan M.;Marks, Michael J.
通讯作者：
Marks, Michael J.