A new era in the genetic analysis of multiple sclerosis
A new era in the genetic analysis of multiple sclerosis
复制标题
多发性硬化症基因分析的新时代
DOI：
10.1097/01.wco.0000227031.39834.31
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发表时间：
2006
影响因子：
4.8
通讯作者：
S. Sawcer
中科院分区：
文献类型：
--
作者：
S. Sawcer
综述的目的这篇综述涵盖了多发性硬化症基因分析的最新进展，以促进对复杂疾病的本质的了解。今年以来，高通量单核苷酸多态性分型技术的早期应用取得了快速进展。最近的发现在过去的12个月里，已经完成了可能是明确的连锁筛查，并开始了与常见变异相关的间接全基因组筛查。与此同时，有史以来第一个系统的混合体作图工作也已经完成，这为欧洲人明显过度的疾病提出了一种可能的解释，并暗示了1号染色体上的一个新的易感基因座。摘要现在很明显，需要在大规模队列中进行基于关联的研究，以揭示多发性硬化症易感性的遗传基础。重要的是，必要的工具现在显然已经到位，今后几年可能会出现令人振奋的事态发展。
Purpose of reviewThis review covers the latest developments in the genetic analysis of multiple sclerosis in the context of advancing knowledge about the nature of complex disease. This year has seen rapid progress dominated by early applications of high-throughput single-nucleotide polymorphism typing technology. Recent findingsThe last 12 months have seen the completion of what is probably a definitive screen for linkage, together with the beginnings of indirect full-genome screens for association with common variants. Alongside this the first ever systematic admixture mapping effort has also been completed, suggesting a possible explanation for the apparent excess of the condition in Europeans and implicating a novel susceptibility locus on chromosome 1. SummaryIt is now clear that association-based studies in large cohorts will be needed to unravel the genetic basis of susceptibility to multiple sclerosis. Importantly it is also clear that the necessary tools have now arrived and that the next few years are likely to see exciting developments.
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影响因子：
4.4
作者：
DEVLIN, B;RISCH, N
通讯作者：
RISCH, N
用于多发性硬化症连锁的高密度屏幕。
影响因子：
9.8
作者：
Sawcer,Stephen;Ban,Maria;Maranian,Mel;Yeo,TaiWai;Compston,Alastair;Kirby,Andrew;Daly,MarkJ;DeJager,PhilipL;Walsh,Emily;Lander,EricS;Rioux,JohnD;Hafler,DavidA;Ivinson,Adrian;Rimmler,Jacqueline;Gregory,SimonG;Schmidt,S
通讯作者：
Schmidt,S
影响因子：
9.8
作者：
Oksenberg, JR;Barcellos, LF;Hauser, SL
通讯作者：
Hauser, SL
影响因子：
9.8
作者：
Barcellos, LF;Klitz, W;Thomson, G
通讯作者：
Thomson, G
影响因子：
4
作者：
Terwilliger, JD;Haghighi, F;Göring, HH
通讯作者：
Göring, HH