Innate immune detection of bacterial virulence factors via the NLRC4 inflammasome.
Innate immune detection of bacterial virulence factors via the NLRC4 inflammasome.
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DOI：
10.1007/s10875-010-9386-5
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发表时间：
2010-07
影响因子：
9.1
通讯作者：
Warren, Sarah E.
中科院分区：
文献类型：
--
作者：
Miao, Edward A.;Warren, Sarah E.
Cytokine production by innate immune cells is initiated by signaling downstream of pattern recognition receptors, including Toll-like receptors. A subset of cytokines, including IL-1b and IL-18, require post-translational proteolysis before secretion, which provides a second mechanism of regulation. This proteolysis is dependent upon caspase 1, which is activated by Nod-like receptor (NLR) signaling. NLRC4 (previously named Ipaf) activates caspase 1 in response to bacterial virulence factors including type III and IV secretion systems (T3SS and T4SS). NLRC4 recognizes T3SS/T4SS in two ways: indirectly by detecting flagellin, and directly by detecting the T3SS rod protein. Both flagellin and rod protein are unintentionally delivered to the mammalian cytosol by the bacterium through the T3SS.
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DOI：
10.1073/pnas.0913087107
发表时间：
2010-02-16
影响因子：
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