Salmonella--the ultimate insider. Salmonella virulence factors that modulate intracellular survival.

Salmonella--the ultimate insider. Salmonella virulence factors that modulate intracellular survival.
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DOI:
10.1111/j.1462-5822.2009.01368.x
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发表时间:
2009-11
影响因子:
3.4
通讯作者:
Steele-Mortimer O
Steele-Mortimer O
中科院分区:
生物学2区
文献类型:
--
作者:
Ibarra JA;Steele-Mortimer O

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肠道沙门氏菌鼠伤寒血清型是一种常见的兼性胞内病原体,在全球范围内导致数百万人患上食源性肠胃炎。胞内生存和复制是重要的毒力决定因素,该细菌在体内可存在于多种吞噬细胞和非吞噬细胞中。宿主细胞的入侵和胞内生存依赖于两种III型分泌系统,T3SS1和T3SS2,每个系统都转运一组不同的效应蛋白。然而,其他毒力因子,包括离子转运蛋白、超氧化物歧化酶、鞭毛和菌毛,也参与进入和利用胞内生态位。
Salmonella enterica serovar Typhimurium is a common facultative intracellular pathogen that causes food-borne gastroenteritis in millions of people worldwide. Intracellular survival and replication are important virulence determinants and the bacteria can be found in a variety of phagocytic and non-phagocytic cells in vivo. Invasion of host cells and intracellular survival are dependent on two type III secretion systems, T3SS1 and T3SS2, each of which translocates a distinct set of effector proteins. However, other virulence factors including ion transporters, superoxide dismutase, flagella and fimbriae are also involved in accessing and utilizing the intracellular niche.
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