Intratumoral Lymphatic Vessel Density and Clinicopathologic Features of Patients With Early-Stage Cervical Cancer After Radical Hysterectomy
Intratumoral Lymphatic Vessel Density and Clinicopathologic Features of Patients With Early-Stage Cervical Cancer After Radical Hysterectomy
复制标题
早期宫颈癌根治性子宫切除术后患者瘤内淋巴管密度及临床病理特征
DOI：
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发表时间：
2010
期刊：
影响因子：
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通讯作者：
J. Carvalho
中科院分区：
文献类型：
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作者：
Fabricia L. Zaganelli;F. Carvalho;B. G. Almeida;C. Bacchi;J. Góes;M. Calil;E. Baracat;J. Carvalho
前言：淋巴管生成在肿瘤的生长、发展和转移中起着关键作用，但很少有人研究淋巴管密度(LVD)在宫颈癌中的作用。这项回顾性研究的目的是评估根治性子宫切除术后IB至IIA期宫颈癌患者的肿瘤内LVD和其他组织学变量与淋巴转移和生存的关系。方法：2000年至2008年间，144例确诊为宫颈癌的患者接受了根治性子宫切除术。根据国际妇产科联合会的标准进行肿瘤分期，其中IB1期84例，IB2期44例，IIA期16例。用抗人泊多普宁(D2-40)抗体免疫组织化学染色检测LVD。分析LVD与手术切除肿瘤临床病理特征的相关性。结果：肿瘤直径<2 cm者(P=0.001)、肿瘤侵袭深度<1.0 cm者(P=0.007)、早期(P=0.001)、无淋巴结转移者淋巴管密度明显增高(P=0.001)。经多因素分析，与淋巴结转移相关的因素有浸润深度(P=0.027)、淋巴管间隙侵犯(P<；0.001)和宫旁侵犯(P=0.001)。患者死亡的预测因素为国际妇产科联合会分期(P=0.017)、组织学类型(P=0.010)、淋巴结状况(P=0.031)和组织学分级(P=0.041)。淋巴管密度不是淋巴结转移或死亡的预测变量。结论：早期宫颈癌(肿瘤较小、临床分期早、淋巴结阴性)瘤内LVD较大，LVD与淋巴结转移及生存期无关。
Introduction: Lymphangiogenesis plays a key role in tumor growth, progression, and metastasis, yet few studies have investigated lymphatic vessel density (LVD) in cases of cervical cancer. The aim of this retrospective study was to evaluate intratumoral LVD, in addition to other histologic variables, in relation to lymph node metastases and survival of patients with stage IB to IIA cervical cancer after radical hysterectomy. Methods: Between 2000 and 2008, 144 patients had a diagnosis of cervical uterine cancer and underwent radical hysterectomy. Tumor stages for these patients were identified according to the criteria of the International Federation of Gynecology and Obstetrics and included 84 stage IB1, 44 stage IB2, and 16 stage IIA cases. With an antibody directed against human podoplanin (D2-40), immunohistochemical staining was used to measure LVD. The correlation between LVD and clinicopathologic features of the resected tumors was analyzed. Results: Lymphatic vessel density was significantly higher in tumors less than 2 cm in diameter (P = 0.001) and in tumors with 1.0-cm-or-less depth of invasion (P = 0.007), with early stage (P = 0.001), and with negative lymph nodes (P = 0.05). After multivariate analysis, the predictive factors associated with lymph node metastases were depth of infiltration (P = 0.027), lymphovascular space invasion (P < 0.001), and parametrial involvement (P = 0.01). For patient death, the predictive factors were International Federation of Gynecology and Obstetrics stage (P = 0.017), histologic type (P = 0.010), lymph node status (P = 0.031), and histologic grade (P = 0.041). Lymphatic vessel density was not a predictive variable for lymph node metastasis or death. Conclusions: Intratumoral LVD was greater in early cervical cancer (ie, smaller tumors, early clinical stage, and negative lymph nodes), and no relationship between LVD and lymph node metastases or survival was observed.
DOI：
10.1016/j.pathophys.2009.11.003
发表时间：
2010-09
期刊：
Pathophysiology : the official journal of the International Society for Pathophysiology
影响因子：
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作者：
Ran S;Volk L;Hall K;Flister MJ
通讯作者：
Flister MJ
影响因子：
3.1
作者：
Al-Rawi, Mahir A. A.;Jiang, Wen G.
通讯作者：
Jiang, Wen G.