Age- and sex-specific differences in ACL and ACL bundle size during adolescent growth.
Age- and sex-specific differences in ACL and ACL bundle size during adolescent growth.
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DOI：
10.1002/jor.25198
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发表时间：
2022-07
影响因子：
2.8
通讯作者：
Spang, Jeffrey T.
中科院分区：
文献类型：
--
作者：
Cone, Stephanie G.;Barnes, Ryan H.;Howe, Danielle;Fordham, Lynn A.;Fisher, Matthew B.;Spang, Jeffrey T.
前交叉韧带（ACL）损伤在青少年中越来越常见，该年龄组的损伤与许多独特的挑战相关。最近的大型动物研究表明，在骨骼生长过程中，ACL主要束的大小和功能变化不同。为了更好地帮助儿科ACL部分撕裂的临床治疗并更好地预测年龄特异性治疗的结果，需要测量人类在生长过程中ACL束尺寸的变化。因此，本研究的目的是比较青少年受试者ACL及其初级束的长度和横截面积的变化。分析MRI扫描以确定ACL及其前内侧和后外侧束的可见性和完整性。从10-18岁受试者的回顾性数据库中考虑MRI扫描。对ACL及其前内侧束和后外侧束进行分割和重建，并计算其长度和横截面积（CSA）。男性的ACL总长度和CSA大于女性，年龄和性别之间的CSA存在统计学显着相互作用。性别对两束的CSA有显著影响。有趣的是，从13岁左右开始，这些性别依赖性差异出现了中等至大的效应量（范围：d=0.50至d=1.23）。考虑到以前在临床前动物模型中建立的ACL束结构-功能关系，这些发现可能指向青少年人类ACL的生物力学变化。
Anterior cruciate ligament (ACL) injuries are increasingly common in adolescents, and injuries in this age group are associated with many unique challenges. Recent large animal studies suggest that the size and function of the major bundles of the ACL change differently throughout skeletal growth. To better aid clinical treatment of pediatric partial ACL tears and better predict outcomes from age-specific treatments, there is a need to measure changes in ACL bundle size in humans during growth. As such, the objective of this study was to compare changes in the length and cross-sectional area of the ACL and its primary bundles in adolescent human subjects. MRI scans were analyzed to determine the visibility and integrity of the ACL and its anteromedial and posterolateral bundles. MRI scans were considered from a retrospective database of subjects ranging from 10-18 years of age. The ACL and its anteromedial and posterolateral bundles were segmented and reconstructed into 3D models, and length and cross-sectional area (CSA) were calculated. Total ACL length and CSA were greater in males compared to females, with a statistically significant interaction between age and sex for CSA. Sex had a significant effect on the CSA of both bundles. Interestingly, these sex dependent differences emerge with moderate to large effect sizes (range: d=0.50 to d=1.23) beginning around 13 years of age. With considerations of ACL bundle structure-function relationships previously established in preclinical animal models, these findings may point towards biomechanical changes in the adolescent human ACL.
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影响因子：
19.7
作者：
Kim, Hee Kyung;Laor, Tal;Dardzinski, Bernard J.
通讯作者：
Dardzinski, Bernard J.
影响因子：
3.7
作者：
Cone, Stephanie G.;Piercy, Hope E.;Fisher, Matthew B.
通讯作者：
Fisher, Matthew B.
影响因子：
3.8
作者：
Reid, Jonathan C.;Yonke, Bret;Tompkins, Marc
通讯作者：
Tompkins, Marc
影响因子：
8
作者：
Beck, Nicholas A.;Lawrence, J. Todd R.;Tompkins, Marc
通讯作者：
Tompkins, Marc
影响因子：
2.3
作者：
Cone SG;Howe D;Fisher MB
通讯作者：
Fisher MB