Cytoskeleton regulator RNA expression on cancer-associated fibroblasts is associated with prognosis and immunotherapy response in bladder cancer.
Cytoskeleton regulator RNA expression on cancer-associated fibroblasts is associated with prognosis and immunotherapy response in bladder cancer.
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癌症相关成纤维细胞上的细胞骨架调节 RNA 表达与膀胱癌的预后和免疫治疗反应相关。
DOI：
10.1016/j.heliyon.2023.e13707
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发表时间：
2023-03
期刊：
影响因子：
4
通讯作者：
Zhou, Liqun
中科院分区：
文献类型：
--
作者：
Wu, Yucai;Xu, Yangyang;He, Shiming;Li, Yifan;Feng, Ninghan;Fan, Jian;Gong, Yanqing;Li, Xuesong;Zhou, Liqun
据报道，长链非编码RNA（lncRNA）的失调与多种肿瘤相关，其中它们充当肿瘤抑制剂或加速剂。lncRNA CYTOR被鉴定为参与许多癌症的癌基因，如胃癌、结直肠癌、肝细胞癌和肾细胞癌。然而，CYTOR在膀胱癌（BCa）中的作用很少报道。使用来自癌症基因组图谱（TCGA）计划的癌症数据集，我们分析了CYTOR表达与BCa预后价值、致癌途径、抗肿瘤免疫和免疫治疗反应之间的关联。在我们的数据集中进一步验证了CYTOR对尿路上皮癌微环境中免疫浸润模式的影响。单细胞分析揭示了CYTOR在BCa的肿瘤微环境（TME）中的作用。最后，我们评估了北京大学第一医院（PKU-BCa）数据集中BCa中CYTOR的表达及其与BCa恶性表型的相关性。结果表明，CYTOR在多种癌症样本中高度表达，包括BCa，并且CYTOR表达增加导致总生存率（OS）较差。此外，CYTOR的高表达与BCa的临床病理特征（如女性、TNM分期、高组织学分级和非乳头状亚型）显著相关。功能鉴定显示，CYTOR可能参与免疫相关途径和上皮间质转化（EMT）过程。此外，CYTOR与浸润性免疫细胞（包括M2巨噬细胞和调节性T细胞（Tcells））有显著相关性。CYTOR促进癌症相关成纤维细胞（CAF）和巨噬细胞之间的串扰，并介导巨噬细胞的M2极化。相关性分析显示，CYTOR表达与BCa中的程序性细胞死亡-1（PD-1）/程序性死亡配体1（PD-L1）/表达和其他特异性免疫治疗靶点之间呈正相关，这些靶点被认为可预测免疫治疗的疗效。这些结果表明，CYTOR作为一个潜在的生物标志物，用于预测BCa的生存结果，TME细胞浸润特征和免疫治疗反应。
Dysregulation of long noncoding RNAs (lncRNAs) has been reported to be associated with multiple tumors where they act as tumor suppressors or accelerators. The lncRNA CYTOR was identified as an oncogene involved in many cancers, such as gastric cancer, colorectal cancer, hepatocellular carcinoma, and renal cell carcinoma. However, the role of CYTOR in bladder cancer (BCa) has rarely been reported. Using cancer datasets from The Cancer Genome Atlas (TCGA) program, we analyzed the association between CYTOR expression and prognostic value, oncogenic pathways, antitumor immunity and immunotherapy response in BCa. The influence of CYTOR on the immune infiltration pattern in the urothelial carcinoma microenvironment was further verified in our dataset. Single-cell analysis revealed the role of CYTOR in the tumor microenvironment (TME) of BCa. Finally, we evaluated the expression of CYTOR in BCa in the Peking University First Hospital (PKU–BCa) dataset and its correlation with the malignant phenotype of BCa in vitro and in vivo. The results indicated that CYTOR was highly expressed in multiple cancer samples, including BCa, and increased CYTOR expression contributed to poor overall survival (OS). Additionally, elevated CYTOR expression was significantly correlated with clinicopathological features of BCa, such as female sex, advanced TNM stage, high histological grade and non-papillary subtype. Functional characterization revealed that CYTOR may be involved in immune-related pathways and the epithelial mesenchymal transformation (EMT) process. Moreover, CYTOR had a significant association with infiltrating immune cells, including M2 macrophages and regulatory T cells (Tregs). CYTOR facilitates the crosstalk between cancer-associated fibroblasts (CAFs) and macrophages, and mediates M2 polarization of macrophages. Correlation analysis revealed a positive correlation between CYTOR expression and programmed cell death-1 (PD-1)/programmed death ligand 1 (PD-L1)/expression and other targets for specific immunotherapy in BCa, which are recognized to predict the efficacy of immunotherapy. These results suggest that CYTOR serves as a potential biomarker for predicting survival outcome, TME cell infiltration characteristics and immunotherapy response in BCa.
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DOI：
10.1158/1541-7786.mcr-18-0322
发表时间：
2018-10
期刊：
Molecular cancer research : MCR
影响因子：
--
作者：
Reon BJ;Takao Real Karia B;Kiran M;Dutta A
通讯作者：
Dutta A
肿瘤微环境中癌症相关成纤维细胞和免疫细胞之间的串扰：新发现和未来前景。
影响因子：
37.3
作者：
Mao X;Xu J;Wang W;Liang C;Hua J;Liu J;Zhang B;Meng Q;Yu X;Shi S
通讯作者：
Shi S
影响因子：
23.4
作者：
van Dijk N;Funt SA;Blank CU;Powles T;Rosenberg JE;van der Heijden MS
通讯作者：
van der Heijden MS
DOI：
10.1002/cac2.12284
发表时间：
2022-05
期刊：
Cancer communications (London, England)
影响因子：
--
作者：
通讯作者：
--
影响因子：
254.7
作者：
Patel, Vaibhav G.;Oh, William K.;Galsky, Matthew D.
通讯作者：
Galsky, Matthew D.