Epithelial specific splicing regulator proteins as emerging oncogenes in aggressive prostate cancer.
Epithelial specific splicing regulator proteins as emerging oncogenes in aggressive prostate cancer.
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DOI：
10.1038/s41388-023-02838-9
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发表时间：
2023-10
期刊：
影响因子：
8
通讯作者：
Elliott, David J.
中科院分区：
文献类型：
--
作者：
Advani, Rahul;Luzzi, Sara;Scott, Emma;Dalgliesh, Caroline;Weischenfeldt, Joachim;Munkley, Jennifer;Elliott, David J.
前列腺癌的进展与常规癌基因和肿瘤抑制因子的活性有关，并由循环类固醇激素驱动。一个关键问题是如何识别和护理积极发展的前列腺肿瘤。在这里，我们讨论了如何表达的剪接调节ESRP 1和ESRP 2，以及他们的作用作为上皮剪接模式的“主谋”，已被确定为积极增殖的前列腺原发性肿瘤的标志物。我们认为前列腺癌起源于上皮细胞，以及ESRP 1和ESRP 2表达与更侵袭性疾病进展的后续关联，将ESRP 1和ESRP 2鉴定为谱系存活癌基因。为了在未来推动这一领域的发展，重要的是要确定由ESRP 1/2控制的基因表达靶点，这些靶点调节前列腺癌增殖。潜在的未来疗法可以设计成靶向ESRP 1和ESRP 2蛋白活性或其在侵袭性前列腺肿瘤中的调节剪接异构体。这些疗法的设计可能因产生可能促进肿瘤转移的更多间充质剪接环境的风险而复杂化。
Prostate cancer progression is connected to the activity of conventional oncogenes and tumour suppressors and driven by circulating steroid hormones. A key issue has been how to identify and care for aggressively developing prostate tumours. Here we discuss how expression of the splicing regulators ESRP1 and ESRP2, and how their role as “masterminds” of epithelial splicing patterns, have been identified as markers of aggressively proliferating prostate primary tumours. We suggest that the origin of prostate cancer within epithelial cells, and the subsequent association of ESRP1 and ESRP2 expression with more aggressive disease progression, identify ESRP1 and ESRP2 as lineage survival oncogenes. To move this field on in the future it will be important to identify the gene expression targets controlled by ESRP1/2 that regulate prostate cancer proliferation. Potential future therapies could be designed to target ESRP1 and ESRP2 protein activity or their regulated splice isoforms in aggressive prostate tumours. Design of these therapies is potentially complicated by the risk of producing a more mesenchymal splicing environment that might promote tumour metastasis.
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影响因子：
--
作者：
Munkley J;Maia TM;Ibarluzea N;Livermore KE;Vodak D;Ehrmann I;James K;Rajan P;Barbosa-Morais NL;Elliott DJ
通讯作者：
Elliott DJ
影响因子：
--
作者：
Hayakawa, Akira;Saitoh, Masao;Miyazawa, Keiji
通讯作者：
Miyazawa, Keiji
DOI：
10.15252/embj.2021108647
发表时间：
2021-09-15
期刊：
The EMBO journal
影响因子：
--
作者：
Brabletz S;Schuhwerk H;Brabletz T;Stemmler MP
通讯作者：
Stemmler MP
影响因子：
30.8
作者：
Bass, Adam J.;Watanabe, Hideo;Mermel, Craig H.;Yu, Soyoung;Perner, Sven;Verhaak, Roel G.;Kim, So Young;Wardwell, Leslie;Tamayo, Pablo;Gat-Viks, Irit;Ramos, Alex H.;Woo, Michele S.;Weir, Barbara A.;Getz, Gad;Beroukhim, Rameen;O'Kelly, Michael;Dutt, Amit;Rozenblatt-Rosen, Orit;Dziunycz, Piotr;Komisarof, Justin;Chirieac, Lucian R.;LaFargue, Christopher J.;Scheble, Veit;Wilbertz, Theresia;Ma, Changqing;Rao, Shilpa;Nakagawa, Hiroshi;Stairs, Douglas B.;Lin, Lin;Giordano, Thomas J.;Wagner, Patrick;Minna, John D.;Gazdar, Adi F.;Zhu, Chang Qi;Brose, Marcia S.;Cecconello, Ivan;Ribeiro, Ulysses, Jr.;Marie, Suely K.;Dahl, Olav;Shivdasani, Ramesh A.;Tsao, Ming-Sound;Rubin, Mark A.;Wong, Kwok K.;Regev, Aviv;Hahn, William C.;Beer, David G.;Rustgi, Anil K.;Meyerson, Matthew
通讯作者：
Meyerson, Matthew
影响因子：
7.7
作者：
Gokmen-Polar, Yesim;Neelamraju, Yaseswini;Badve, Sunil S.
通讯作者：
Badve, Sunil S.