Microstructural profiles of thalamus and thalamocortical connectivity in patients with disorder of consciousness
Microstructural profiles of thalamus and thalamocortical connectivity in patients with disorder of consciousness
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意识障碍患者丘脑和丘脑皮质连接的微观结构特征
DOI：
10.1002/jnr.24921
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发表时间：
2021-11
影响因子：
4.2
通讯作者：
Benyan Luo
中科院分区：
文献类型：
--
作者：
Yamei Yu;Weihao Zheng;Xufei Tan;Xiaoxia Li;Xiaotong Zhang;Jian Gao;Gang Pan;Dan Wu;Benyan Luo
Thalamus and thalamocortical connectivity are crucial for consciousness; however, their microstructural changes in patients with a disorder of consciousness (DOC) have not yet been thoroughly characterized. In the present study, we applied the novel fixel‐based analysis to comprehensively investigate the thalamus‐related microstructural abnormalities in 10 patients with DOC using 7‐T diffusion‐weighted imaging data. We found that compared to healthy controls, patients with DOC showed reduced fiber density (FD) and fiber density and cross‐section (FDC) in the mediodorsal, anterior, and ventral anterior thalamic nuclei, while fiber‐bundle cross‐section (FC) was not significantly altered in the thalamus. Impaired thalamocortical connectivity in the DOC cohort was mainly connected to the middle frontal gyrus, anterior cingulate gyrus, fusiform gyrus, and sensorimotor cortices, including the precentral gyrus and postcentral gyrus, with predominant microstructural abnormalities in FD and FDC. Correlation analysis showed that FC of the right mediodorsal thalamus was negatively correlated with the level of consciousness. Our results suggest that microstructural abnormalities of thalamus and thalamocortical connectivity in DOC were mainly attributed to axonal injury. In particular, the microstructural integrity of the thalamus is a vital factor in consciousness generation.
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