L-dopa impairs learning, but spares generalization, in Parkinson's disease.
L-dopa impairs learning, but spares generalization, in Parkinson's disease.
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左旋多巴会损害帕金森病的学习能力，但不会影响泛化能力。
DOI：
10.1016/j.neuropsychologia.2005.07.013
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发表时间：
2006
期刊：
影响因子：
2.6
通讯作者：
Gluck,MarkA
中科院分区：
文献类型：
--
作者：
Shohamy,Daphna;Myers,CatherineE;Geghman,KindiyaD;Sage,Jacob;Gluck,MarkA
In this study we examined the effect of dopaminergic modulation on learning and memory. Parkinson's patients were tested ‘on’ versus ‘off’ dopaminergic medication, using a two-phase learning and transfer task. We found that dopaminergic medication was associated with impaired learning of an incrementally acquired concurrent discrimination task, while patients withdrawn from dopaminergic medication performed as well as controls. In addition, we found a dissociation of the effect of medication within a single two-phase task: patients tested ‘on’ medication were not impaired at the ability to generalize based on learned information. The deficit among medicated patients appeared to be related specifically to the concurrent, incremental, feedback-based nature of the task: such a deficit was not found in a version of the task in which demands for concurrent error-processing learning were reduced. Taken together with a growing body of evidence emphasizing a role for midbrain dopamine in error-correcting, feedback-based learning processes, the present results suggest a framework for understanding previously conflicting results regarding the effect of medication on learning and memory in Parkinson's disease.
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印度牙周病的 X 线摄影调查。
DOI：
--
发表时间：
1949
期刊：
The Journal of the American Dental Association (1939)
影响因子：
--
作者：
C. Day;K. L. Shourie
通讯作者：
K. L. Shourie
HL-A2抗原与青壮年各种牙周病的关系。
DOI：
--
发表时间：
1975
期刊：
Journal of dentistry research
影响因子：
--
作者：
R. Kaslick;T. L. West;A. I. Chasens;P. Terasaki;R. Lazzara;S. Weinberg
通讯作者：
S. Weinberg
影响因子：
4.3
作者：
Page,RC;Bowen,T;Altman,L;Vandesteen,E;Ochs,H;Mackenzie,P;Osterberg,S;Engel,LD;Williams,BL
通讯作者：
Williams,BL
幼年牙周炎的常染色体隐性遗传：假设检验
影响因子：
3.5
作者：
L. Saxén;H. Nevanlinna
通讯作者：
H. Nevanlinna
青少年牙周炎的免疫学特征。
DOI：
--
发表时间：
1984
期刊：
The Journal of Periodontology
影响因子：
--
作者：
Jon B. Suzuki;Jon B. Suzuki;Jon B. Suzuki;B. Collison;W. Falkler;Robert K. Nauman
通讯作者：
Robert K. Nauman