Lesions to the CA2 region of the hippocampus impair social memory in mice.
Lesions to the CA2 region of the hippocampus impair social memory in mice.
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DOI：
10.1111/ejn.12689
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发表时间：
2014-11
期刊：
影响因子：
--
通讯作者：
Caldwell HK
中科院分区：
文献类型：
--
作者：
Stevenson EL;Caldwell HK
海马体CA2区域的功能尚不清楚。虽然CA1和CA3区域已被广泛研究，但多年来CA2区域主要被视为两者之间的连接区域。然而，众所周知，CA2区域具有不同于海马体其他部分的独特的神经化学和结构特征，近年来，有人认为CA2区域可能在正常社会行为所需的基于嗅觉的记忆的形成和回忆中发挥作用。虽然这一假设得到了包括CA2区域在内的海马病变研究的支持，但没有研究试图专门损害小鼠海马的CA2区域，以确定对社会识别、记忆和嗅觉的影响。为了填补这一知识空白，我们试图对小鼠CA2区域进行兴奋性毒性n -甲基- d天冬氨酸（NMDA）损伤，并确定其对社会识别记忆的影响。我们预测CA2区域的损伤会损害社会识别记忆。然后我们继续测试CA2损伤小鼠的嗅觉，因为社会记忆需要一个功能性的嗅觉系统。与我们的预测一致，我们发现CA2损伤动物的社会认知受损。这些发现很重要，因为它们证实了海马体的CA2区域是调节社会识别记忆的神经回路的一部分，这可能对我们理解跨物种社会行为的神经调节有影响。
The function of the CA2 region of the hippocampus is poorly understood. While the CA1 and CA3 regions have been extensively studied, for years the CA2 region has primarily been viewed as a linking area between the two. However, the CA2 region is known to have distinct neurochemical and structural features that are different from the other parts of hippocampus and in recent years it has been suggested that the CA2 region may play a role in the formation and or recall of olfactory-based memories needed for normal social behavior. While this hypothesis has been supported by hippocampal lesion studies that have included the CA2 region, no studies have attempted to specifically lesion the CA2 region of the hippocampus in mice to determine the effects on social recognition memory and olfaction. To fill this knowledge gap, we sought to perform excitotoxic N-methyl-D aspartate (NMDA) lesions of the CA2 region in mice and determine the effects on social recognition memory. We predicted that lesions of the CA2 region would impair social recognition memory. We then went on to test olfaction in CA2 lesioned mice since social memory requires a functional olfactory system. Consistent with our prediction, we found that CA2 lesioned animals have impaired social recognition. These findings are significant because they confirm that the CA2 region of the hippocampus is a part of the neural circuitry that regulates social recognition memory, which may have implications for our understanding of the neural regulation of social behavior across species.
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影响因子：
1.3
作者：
delBarco-Trillo, Javier;LaVenture, Alex B.;Johnston, Robert E.
通讯作者：
Johnston, Robert E.
DOI：
10.1016/s0163-1047(89)90608-0
发表时间：
1989-01-01
期刊：
BEHAVIORAL AND NEURAL BIOLOGY
影响因子：
--
作者：
HUCK, UW;LISK, RD;EVANS, AB
通讯作者：
EVANS, AB
影响因子：
3.5
作者：
Bartesaghi, R;Gessi, T
通讯作者：
Gessi, T
影响因子：
1.9
作者：
Deacon, RMJ;Bannerman, DM;Rawlins, JNP
通讯作者：
Rawlins, JNP
DOI：
10.1016/s0163-1047(87)90544-9
发表时间：
1987-07-01
期刊：
BEHAVIORAL AND NEURAL BIOLOGY
影响因子：
--
作者：
INGERSOLL, DW;WEINHOLD, LL
通讯作者：
WEINHOLD, LL