Antinuclear Antibodies With a Nucleolar Pattern Are Associated With a Significant Reduction in the Overall Survival of Patients With Leukemia: A Retrospective Cohort Study.
Antinuclear Antibodies With a Nucleolar Pattern Are Associated With a Significant Reduction in the Overall Survival of Patients With Leukemia: A Retrospective Cohort Study.
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核仁型抗核抗体与白血病患者总生存率显著降低相关：一项回顾性队列研究
DOI：
10.3389/fonc.2021.631038
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发表时间：
2021
影响因子：
4.7
通讯作者：
Cai J
中科院分区：
文献类型：
--
作者：
Wang R;Zhao H;Liu Y;Kang B;Cai J
据报道，抗核抗体(Ana)与癌症有关。然而，不同的ANA模式在癌症中的作用尚不清楚，特别是在白血病中。本研究旨在通过回顾性队列研究ANA模式与白血病预后之间的关系。本研究纳入河南省人民医院2014年1月至2018年12月初诊的成人白血病患者429例，包括初诊时无ANA阳性的患者、既往存在的自身免疫性疾病、传染病等信息。最终样本包括196名成年患者。用多变量Cox比例风险模型估计ANA分型的死亡结局风险，用Kaplan-Meier曲线分析ANA分型的总生存期。与性别、年龄、白血病免疫表型、细胞遗传学异常、治疗和输血无关，核仁模式的ANA与ANA阴性的白血病死亡结局的风险增加两倍相关。进一步分析显示，这种关联在老年患者(≥60岁)和接受酪氨酸激酶抑制剂或化疗治疗的患者中更为显著(交互作用P=0.042和0.010)。值得注意的是，核仁模式的患者比非核仁模式或无核仁模式的患者存活时间更短(p<；0.001)。核仁模式的ANA是预后不良的重要预测指标，为白血病患者的预后评估提供线索。
Antinuclear antibodies (ANAs) have been reported to be associated with cancers. However, the role of different ANA patterns in cancers is poorly understood, especially in leukemia. This study aimed to investigate the association between ANA patterns and the outcome of leukemia in a retrospective cohort. A total of 429 adult patients initially diagnosed with leukemia at Henan Provincial People’s Hospital from January 2014 to December 2018 were included in this study, including information on patients without positive ANAs at the time of initial diagnosis, preexisting autoimmune diseases, infectious diseases, etc. The data were retrieved up to December 2020. The final sample included 196 adult patients. The risk of death outcome according to ANA patterns was estimated using multivariable Cox proportional hazards models and the overall survival for ANA patterns was analyzed using Kaplan–Meier curve. ANAs with a nucleolar pattern versus negative ANA were associated with a two-fold increased risk of death outcome in leukemia, independent of sex, age, leukemia immunophenotype, cytogenetic abnormality, treatment, and blood transfusion. Further analysis revealed that the association was more significant in elder patients (≥60 years) and patients treated with tyrosine kinase inhibitor or chemotherapy (P for interaction = 0.042 and 0.010). Notably, the patients with a nucleolar pattern had shorter survival than the patients with a non-nucleolar pattern or without ANA (p < 0.001). ANAs with a nucleolar pattern are a significant predictor of poor prognosis, providing clues for prognostic assessment in patients with leukemia.
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影响因子：
158.5
作者：
Gogas, H;Ioannovich, J;Kirkwood, JM
通讯作者：
Kirkwood, JM
影响因子：
11.2
作者：
Fernández-Madrid, F;Tang, NM;Karvonen, RL
通讯作者：
Karvonen, RL
影响因子：
7.3
作者：
Ludwig RJ;Vanhoorelbeke K;Leypoldt F;Kaya Z;Bieber K;McLachlan SM;Komorowski L;Luo J;Cabral-Marques O;Hammers CM;Lindstrom JM;Lamprecht P;Fischer A;Riemekasten G;Tersteeg C;Sondermann P;Rapoport B;Wandinger KP;Probst C;El Beidaq A;Schmidt E;Verkman A;Manz RA;Nimmerjahn F
通讯作者：
Nimmerjahn F
影响因子：
4.4
作者：
Gilbert, Jacqueline A.;Gianoukakis, Andrew G.;Banga, J. Paul
通讯作者：
Banga, J. Paul
影响因子：
15.9
作者：
Sauer, Aisha V.;Morbach, Henner;Meffre, Eric
通讯作者：
Meffre, Eric