Iron stores, response to alpha-interferon therapy, and effects of iron depletion in chronic hepatitis C.
Iron stores, response to alpha-interferon therapy, and effects of iron depletion in chronic hepatitis C.
复制标题
铁储备、α-干扰素治疗的反应以及铁缺乏对慢性丙型肝炎的影响。
DOI：
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
Gemino Fiorelli
中科院分区：
文献类型：
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作者：
A. Piperno;Maurizio Sampietro;R. D'Alba;L. Roffi;S. Fargion;Stefania Parma;Carlo Nicoli;N. Corbetta;Massimo Pozzi;Valeria Arosio;G. Boari;Gemino Fiorelli
我们研究了81例慢性丙型肝炎患者，以探讨铁和α-干扰素反应之间的关系。61例患者（A组）接受α-干扰素治疗，与铁状态无关，而20例（B组）铁过载患者在α-干扰素治疗前铁耗竭。在A组中，21例患者对α-干扰素有反应，40例无反应。铁指数增加在无应答者中比应答者更常见。多变量分析显示，在评估的自变量中，只有γ-GT和肝脏铁浓度预测治疗结果。静脉切开治疗后，B组患者（196 +/- 122 IU/l vs 82 +/- 37 IU/l，p < 10（-6））和A组12例无应答者（198 +/- 89 IU/l vs 107 +/- 81 IU/l，p < 10（-6））的血清丙氨酸氨基转移酶均显著下降。在16名铁缺乏患者中，每组8名，随后用α-干扰素治疗仅在1名患者中产生反应。这些结果表明，肝铁增加是慢性丙型肝炎α-干扰素应答的一个负面预后因素。在所有接受治疗的患者中，铁缺乏对血清丙氨酸氨基转移酶有有益的影响，但不能改善对α-干扰素的反应。
We studied 81 patients with chronic hepatitis C to investigate the relationship between iron and alpha-interferon response. Sixty-one patients (group A) were given alpha-interferon irrespective of iron status, whereas 20 (group B) with iron overload, were iron depleted before alpha-interferon therapy. In group A, 21 patients responded to alpha-interferon and 40 were non-responders. Increased iron indices were significantly more frequent in non-responders than responders. Multivariate analysis showed that among the independent variables evaluated, only gamma-GT and liver iron concentration predicted therapy outcome. After phlebotomy treatment, serum alanine aminotransferase fell significantly both in patients of group B (196 +/- 122 IU/l vs 82 +/- 37 IU/l, p < 10(-6)) and in 12 non-responders of group A (198 +/- 89 IU/l vs 107 +/- 81 IU/l, p < 10(-6)). In 16 iron depleted patients, eight from each group, subsequent treatment with alpha-interferon produced a response in only one patient. These results suggest that increased liver iron is a negative prognostic factor for alpha-interferon response in chronic hepatitis C. Iron depletion had a beneficial effect on serum alanine aminotransferase in all the patients treated, but did not improve the response to alpha-interferon.
影响因子：
29.4
作者：
OLYNYK, JK;REDDY, KR;BACON, BR
通讯作者：
BACON, BR