Circulating 25-hydroxyvitamin D, nasopharyngeal airway metabolome, and bronchiolitis severity.
Circulating 25-hydroxyvitamin D, nasopharyngeal airway metabolome, and bronchiolitis severity.
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DOI：
10.1111/all.13379
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发表时间：
2018-05
期刊：
影响因子：
12.4
通讯作者：
Camargo CA Jr
中科院分区：
文献类型：
--
作者：
Hasegawa K;Stewart CJ;Celedón JC;Mansbach JM;Tierney C;Camargo CA Jr
循环中低水平的25-羟基维生素D(25OHD)是儿童急性呼吸道感染(如毛细支气管炎)的危险因素。然而，关于循环中的25OHD与靶器官中的许多下游功能分子--如呼吸道--以及与临床结果的关系，人们知之甚少。在这项针对1岁毛细支气管炎住院婴儿的前瞻性多中心研究中，我们测量了144例鼻咽部呼吸道样本的血清25OHD水平和代谢产物。在已鉴定的254种代谢物中，我们定义了一组20种代谢物，它们与较低的血清25OHD和较高的维生素D结合蛋白水平有关。在这些代谢物中，有9种代谢物与使用正压通气的风险显著增加相关。这些代谢物是与促炎脂肪酸(棕榈酸酯、花生四烯酸、亚油酸盐和硬脂酸酯)、神经鞘蛋白、α-羟基异戊酸酯、2-羟基丁酸酯和3-(4-羟基苯基)乳酸酯化的甘油磷胆碱(均为FDR<；0.05)。根据多中心数据，维生素D相关的呼吸道代谢物与毛细支气管炎严重程度的风险相关。
Low circulating 25-hydroxyvitamin D (25OHD) levels are a risk factor for acute respiratory infection (e.g., bronchiolitis) in children. However, little is known about the relation of circulating 25OHD with the many downstream functional molecules in target organs – such as the airway – and with clinical outcomes. In this prospective multicenter study of infants (age <1 year) hospitalized with bronchiolitis, we measured serum 25OHD levels and profiled the metabolome of 144 nasopharyngeal airway samples. Among 254 metabolites identified, we defined a set of 20 metabolites that are related to lower serum 25OHD and higher vitamin D-binding protein levels. Of these metabolites, 9 metabolites were associated with a significantly higher risk of positive pressure ventilation use. These metabolites were glycerophosphocholines esterified with proinflammatory fatty acids (palmitate, arachidonate, linoleate, and stearate), sphingomyelins, alpha-hydroxyisovalerate, 2-hydroxybutyrate, and 3-(4-hydroxyphenyl)lactate (all FDR<0.05). Based on the multicenter data, vitamin D-related airway metabolites were associated with risks of bronchiolitis severity.
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影响因子：
12.4
作者：
Hasegawa K;Mansbach JM;Ajami NJ;Petrosino JF;Freishtat RJ;Teach SJ;Piedra PA;Camargo CA Jr
通讯作者：
Camargo CA Jr
影响因子：
3.7
作者：
Esposito S;Lelii M
通讯作者：
Lelii M
影响因子：
15.1
作者：
Lasky-Su, Jessica;Dahlin, Amber;Christopher, Kenneth B.
通讯作者：
Christopher, Kenneth B.
影响因子：
8
作者：
Ralston, Shawn L.;Lieberthal, Allan S.;Hernandez-Cancio, Sinsi
通讯作者：
Hernandez-Cancio, Sinsi
DOI：
10.1136/bmj.i6583
发表时间：
2017-02-15
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Martineau AR;Jolliffe DA;Hooper RL;Greenberg L;Aloia JF;Bergman P;Dubnov-Raz G;Esposito S;Ganmaa D;Ginde AA;Goodall EC;Grant CC;Griffiths CJ;Janssens W;Laaksi I;Manaseki-Holland S;Mauger D;Murdoch DR;Neale R;Rees JR;Simpson S Jr;Stelmach I;Kumar GT;Urashima M;Camargo CA Jr
通讯作者：
Camargo CA Jr