The relationship between nasopharyngeal CCL5 and microbiota on disease severity among infants with bronchiolitis.
The relationship between nasopharyngeal CCL5 and microbiota on disease severity among infants with bronchiolitis.
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DOI：
10.1111/all.13160
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发表时间：
2017-11
期刊：
影响因子：
12.4
通讯作者：
Camargo CA Jr
中科院分区：
文献类型：
--
作者：
Hasegawa K;Mansbach JM;Ajami NJ;Petrosino JF;Freishtat RJ;Teach SJ;Piedra PA;Camargo CA Jr
新出现的证据表明，气道微生物群在病毒性细支气管炎病理生物学中起着重要作用。然而，关于气道微生物群和CCL 5在毛细支气管炎婴儿中的联合作用知之甚少。在这项2011-2014年期间因毛细支气管炎住院的1，005名婴儿（年龄<1岁）的多中心前瞻性队列研究中，我们观察到鼻咽气道CCL 5水平与微生物群特征之间在重症监护使用风险（P相互作用=0.02）和住院时间≥3天（P相互作用=0.03）方面存在显著的相互作用。在CCL 5水平较低的婴儿中，与莫拉菌属优势菌群相比，嗜血菌属优势菌群与重症监护使用风险较高（OR，3.20; 95%CI，1.18-8.68; P=0.02）和住院时间≥3天（OR，4.14; 95%CI，2.08-8.24; P<0.001）相关。相反，在CCL 5水平较高的患者中，微生物群特征与这些严重程度结果之间没有显著相关性（所有P≥0.10）。
Emerging evidence suggests that the airway microbiota plays an important role in viral bronchiolitis pathobiology. However, little is known about the combined role of airway microbiota and CCL5 in infants with bronchiolitis. In this multicenter prospective cohort study of 1,005 infants (age <1 year) hospitalized for bronchiolitis during 2011–2014, we observed statistically-significant interactions between nasopharyngeal airway CCL5 levels and microbiota profiles with regard to the risk of both intensive care use (Pinteraction=0.02) and hospital length-of-stay ≥3 days (Pinteraction=0.03). Among infants with lower CCL5 levels, the Haemophilus-dominant microbiota profile was associated with a higher risk of intensive care use (OR, 3.20; 95%CI, 1.18–8.68; P=0.02) and hospital length-of-stay ≥3 days (OR, 4.14; 95%CI, 2.08–8.24; P<0.001) compared to the Moraxella-dominant profile. Conversely, among those with higher CCL5 levels, there were no significant associations between the microbiota profiles and these severity outcomes (all P≥0.10).
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影响因子：
8
作者：
Ralston, Shawn L.;Lieberthal, Allan S.;Hernandez-Cancio, Sinsi
通讯作者：
Hernandez-Cancio, Sinsi
DOI：
10.1183/13993003.00152-2016
发表时间：
2016-11
期刊：
The European respiratory journal
影响因子：
--
作者：
Hasegawa K;Mansbach JM;Ajami NJ;Espinola JA;Henke DM;Petrosino JF;Piedra PA;Shaw CA;Sullivan AF;Camargo CA Jr;the MARC-35 Investigators
通讯作者：
the MARC-35 Investigators
影响因子：
8
作者：
Hasegawa, Kohei;Tsugawa, Yusuke;Camargo, Carlos A., Jr.
通讯作者：
Camargo, Carlos A., Jr.
影响因子：
64.5
作者：
Elinav E;Strowig T;Kau AL;Henao-Mejia J;Thaiss CA;Booth CJ;Peaper DR;Bertin J;Eisenbarth SC;Gordon JI;Flavell RA
通讯作者：
Flavell RA
影响因子：
15.5
作者：
Marsh RL;Kaestli M;Chang AB;Binks MJ;Pope CE;Hoffman LR;Smith-Vaughan HC
通讯作者：
Smith-Vaughan HC