The Accumulation and Molecular Effects of Trimethylamine N-Oxide on Metabolic Tissues: It's Not All Bad.
The Accumulation and Molecular Effects of Trimethylamine N-Oxide on Metabolic Tissues: It's Not All Bad.
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三甲胺N-氧化物在新陈代谢组织中的积累和分子效应：并不全是坏事。
DOI：
10.3390/nu13082873
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发表时间：
2021-08-21
期刊：
影响因子：
5.9
通讯作者：
Tessem JS
中科院分区：
文献类型：
--
作者：
Krueger ES;Lloyd TS;Tessem JS
由于血清中氧化三甲胺（TMAO）水平的升高首先与心血管疾病（CVD）的风险增加有关，因此TMAO在慢性疾病中的研究呈指数增长。我们现在知道，血清TMAO积累始于微生物组-肝-肾轴上的饮食胆碱代谢，这在发病过程中通常失调。虽然CVD研究将TMAO与血管组织中的动脉粥样硬化机制联系起来，但其对代谢组织的分子效应尚不清楚。在这里，我们报告了TMAO在代谢疾病背景下的研究现状，包括肝脏，肾脏，大脑，脂肪和肌肉。由于血糖管理不良是代谢性疾病的标志，我们还探讨了TMAO对胰岛素抵抗和胰岛素产生的可变影响。在代谢组织中，肝脏TMAO研究是最常见的，而其对其他组织（包括产生胰岛素的胰腺β细胞）的影响在很大程度上尚未探索。对包括肥胖、糖尿病、肝病、慢性肾病和认知疾病在内的疾病的研究表明，与健康对照相比，TMAO在病理条件下的作用是独特的。我们的结论是，分子TMAO的影响是高度依赖于上下文，并呼吁进一步的研究，以澄清在代谢疾病研究中观察到的有害和有益的分子效应。
Since elevated serum levels of trimethylamine N-oxide (TMAO) were first associated with increased risk of cardiovascular disease (CVD), TMAO research among chronic diseases has grown exponentially. We now know that serum TMAO accumulation begins with dietary choline metabolism across the microbiome-liver-kidney axis, which is typically dysregulated during pathogenesis. While CVD research links TMAO to atherosclerotic mechanisms in vascular tissue, its molecular effects on metabolic tissues are unclear. Here we report the current standing of TMAO research in metabolic disease contexts across relevant tissues including the liver, kidney, brain, adipose, and muscle. Since poor blood glucose management is a hallmark of metabolic diseases, we also explore the variable TMAO effects on insulin resistance and insulin production. Among metabolic tissues, hepatic TMAO research is the most common, whereas its effects on other tissues including the insulin producing pancreatic β-cells are largely unexplored. Studies on diseases including obesity, diabetes, liver diseases, chronic kidney disease, and cognitive diseases reveal that TMAO effects are unique under pathologic conditions compared to healthy controls. We conclude that molecular TMAO effects are highly context-dependent and call for further research to clarify the deleterious and beneficial molecular effects observed in metabolic disease research.
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8 周纯素饮食对血糖异常或肥胖成人血浆三甲胺-N-氧化物和攻击后血糖的评估。
DOI：
10.1093/jn/nxab046
发表时间：
2021-07-01
期刊：
The Journal of nutrition
影响因子：
--
作者：
Argyridou S;Davies MJ;Biddle GJH;Bernieh D;Suzuki T;Dawkins NP;Rowlands AV;Khunti K;Smith AC;Yates T
通讯作者：
Yates T
DOI：
10.1159/000484623
发表时间：
2017
期刊：
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
影响因子：
--
作者：
Boini KM;Hussain T;Li PL;Koka S
通讯作者：
Koka S
影响因子：
6
作者：
ALWAIZ, M;AYESH, R;SMITH, RL
通讯作者：
SMITH, RL
影响因子：
2.9
作者：
Bennion, BJ;DeMarco, ML;Daggett, V
通讯作者：
Daggett, V
影响因子：
4.6
作者：
Balagam, Bhararthi;Richardson, David E.
通讯作者：
Richardson, David E.