Evaluation of an 8-Week Vegan Diet on Plasma Trimethylamine-N-Oxide and Postchallenge Glucose in Adults with Dysglycemia or Obesity.
Evaluation of an 8-Week Vegan Diet on Plasma Trimethylamine-N-Oxide and Postchallenge Glucose in Adults with Dysglycemia or Obesity.
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8 周纯素饮食对血糖异常或肥胖成人血浆三甲胺-N-氧化物和攻击后血糖的评估。
DOI：
10.1093/jn/nxab046
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发表时间：
2021-07-01
期刊：
影响因子：
--
通讯作者：
Yates T
中科院分区：
文献类型：
--
作者：
Argyridou S;Davies MJ;Biddle GJH;Bernieh D;Suzuki T;Dawkins NP;Rowlands AV;Khunti K;Smith AC;Yates T
三甲胺N-氧化物（TMAO）是一种由肠道响应（部分）肉类消费而产生的代谢物，与心脏代谢健康不良有关。我们研究了8周纯素饮食，随后4周无限制饮食对肥胖或发育不良的人类杂食动物的葡萄糖耐量和血浆TMAO的影响。这项干预性单组前瞻性试验涉及23名患有功能障碍[糖化血红蛋白≥ 5.7%且≤8%（39-64 mmol/mol）]或肥胖（BMI ≥ 30 kg/m2）的经常吃肉者，年龄为57.8 ± 10.0岁。参与者[14名男性（60.9%）和9名女性（39.1%）]被支持遵循素食饮食8周，然后是4周的无限制饮食。在基线、纯素饮食期间（第1周和第8周）和无限制饮食期（第12周）后评估主要结局（血浆TMAO和葡萄糖）。空腹后评估TMAO，并使用180分钟口服葡萄糖耐量试验测量葡萄糖的时间平均总AUC。使用具有可交换相关结构的广义估计方程模型评估较基线的变化，调整年龄、性别、种族和体重。TMAO水平与基线相比，纯素饮食第1周和第8周后，（97.5% CI，6.61-17.3）μmol/L至5.66（97.5% CI，4.56-7.02）μmol/L和6.38（97.5% CI，5.25-7.74）μmol/L;然而，恢复无限制饮食后，水平在第12周反弹（17.5 μmol/L; 97.5% CI，7.98-38.4）。与基线相比，第1周和第8周后餐后血糖水平（边际均值）分别从8. 07（97. 5% CI，7. 24 - 8. 90）mmol/L降至7. 14（97. 5% CI，6. 30 - 7. 98）mmol/L和7. 34（97. 5% CI，6. 63 - 8. 04）mmol/L。葡萄糖和TMAO的结果与体重减轻无关。在第8周观察到血脂和肾功能标志物改善。这些研究结果表明，纯素饮食是一种有效的策略，可以改善糖尿病或肥胖患者的葡萄糖耐量并降低血浆TMAO。本研究在clinicaltrials.gov上注册为NCT 03315988。
Trimethylamine N-oxide (TMAO), a metabolite generated by the gut in response (in part) to meat consumption, is linked to poor cardiometabolic health. We investigate the effect of an 8-week vegan diet, followed by a 4-week period of unrestricted diet, on glucose tolerance and plasma TMAO in human omnivores with obesity or dysglycemia. This interventional single-group prospective trial involved 23 regular meat eaters with dysglycemia [glycated hemoglobin ≥ 5.7% and ≤8% (39–64 mmol/mol)], or obesity (ΒΜΙ ≥ 30 kg/m2) aged 57.8 ± 10.0 years. Participants [14 men (60.9%) and 9 women (39.1%)] were supported in following a vegan diet for 8 weeks, followed by 4 weeks of unrestricted diet. The primary outcomes (plasma TMAO and glucose) were assessed at baseline, during the vegan diet (weeks 1 and 8), and after the unrestricted diet period (week 12). TMAO was assessed after fasting and glucose was measured as a time-averaged total AUC using a 180-minute oral-glucose-tolerance test. Generalized estimating equation models with an exchangeable correlation structure were used to assess changes from baseline, adjusting for age, sex, ethnicity, and weight. TMAO levels (marginal mean) were reduced after weeks 1 and 8 of a vegan diet compared to baseline, from 10.7 (97.5% CI, 6.61–17.3) μmol/L to 5.66 (97.5% CI, 4.56–7.02) μmol/L and 6.38 (97.5% CI, 5.25–7.74) μmol/L, respectively; however, levels rebounded at week 12 after resumption of an unrestricted diet (17.5 μmol/L; 97.5% CI, 7.98–38.4). Postprandial glucose levels (marginal means) were reduced after weeks 1 and 8 compared to baseline, from 8.07 (97.5% CI, 7.24–8.90) mmol/L to 7.14 (97.5% CI, 6.30–7.98) mmol/L and 7.34 (97.5% CI, 6.63–8.04) mmol/L, respectively. Results for glucose and TMAO were independent of weight loss. Improvements in the lipid profile and markers of renal function were observed at week 8. These findings suggest that a vegan diet is an effective strategy for improving glucose tolerance and reducing plasma TMAO in individuals with dysglycemia or obesity. This study was registered at clinicaltrials.gov as NCT03315988.
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影响因子：
19.6
作者：
Ninomiya, T;Kiyohara, Y;Iida, M
通讯作者：
Iida, M
影响因子：
5.2
作者：
Cho, Clara E.;Taesuwan, Siraphat;Caudill, Marie A.
通讯作者：
Caudill, Marie A.
影响因子：
5.4
作者：
Heianza Y;Ma W;Manson JE;Rexrode KM;Qi L
通讯作者：
Qi L
DOI：
10.1097/00008483-200407000-00004
发表时间：
2004-07-01
期刊：
Journal of cardiopulmonary rehabilitation
影响因子：
--
作者：
Barnard, Neal D;Scialli, Anthony R;Lanou, Amy J
通讯作者：
Lanou, Amy J
DOI：
10.1016/s0022-3182(00)70590-5
发表时间：
2000-11-01
期刊：
JOURNAL OF NUTRITION EDUCATION
影响因子：
--
作者：
Barnard, N;Scialli, AR;Edmonds, K
通讯作者：
Edmonds, K