Comparison of HER2 and Lauren Classification between Biopsy and Surgical Resection Samples, Primary and Metastatic Samples of Gastric Cancer.
Comparison of HER2 and Lauren Classification between Biopsy and Surgical Resection Samples, Primary and Metastatic Samples of Gastric Cancer.
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胃癌活检和手术切除样本、原发性和转移性样本之间 HER2 和 Lauren 分类的比较
DOI：
10.7150/jca.19984
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发表时间：
2017
影响因子：
3.9
通讯作者：
Xu RH
中科院分区：
文献类型：
--
作者：
Qiu MZ;Shi SM;Chen M;Wang J;Wu QN;Sheng H;Zhang HZ;Yun JP;Zhou ZW;Wang FH;Yang DJ;Xu RH
Purpose: Patients with advanced or metastatic adenocarcinoma of the stomach or esophagogastric junction for whom trastuzumab therapy is being considered, assessment for tumor human epidermal growth factor receptor-2 (HER2) status is necessary. Can the HER2 status and Lauren classification of the biopsy sample truly represent the HER2 status in the gastric cancer? Methods: Formalin-fixed, paraffin-embedded sections of 116 pair surgically resected and biopsy specimens as well as 80 pair primary and metastatic lesions of gastric cancer patients were analyzed. Protein expression was assessed using immunohistochemistry (IHC) and graded by the modified scoring criteria for gastric cancer. Gene amplification was evaluated by fluorescence in situ hybridization (FISH) in IHC 2+ cases. Results: The positive rate of HER2 was 11.2% in both surgical and biopsy samples. The consistent rate of HER2 expression was 91.4% (106/116) between biopsy and surgical samples, P=0.666. The positive rate of HER2 was 20.5% in primary and 15.9% in metastatic samples, P=0.1876. The consistent rate of HER2 expression was 90.9% (40/44) between primary and metastatic samples, P=0.580. The consistent rate of Lauren classification was 64.7% (75/116) between biopsy and surgical sample, and 92.5% (74/80) between primary and metastatic samples. Discussion: For gastric cancer, HER2 expression and Lauren classification were highly homogenous in biopsy and surgical samples, primary and their corresponding metastatic samples. The high concordance observed between these two cohorts indicated that the HER2 examination and Lauren classification of biopsy samples from the primary tumor could well represent the metastatic lesions of the patients.
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配对原发性胃癌和转移瘤之间 HER2 的不一致：一项荟萃分析
影响因子：
5.1
作者：
Peng, Zhi;Zou, Jianling;Shen, Lin
通讯作者：
Shen, Lin
DOI：
10.1111/apm.1965.64.1.31
发表时间：
1965-01-01
期刊：
ACTA PATHOLOGICA ET MICROBIOLOGICA SCANDINAVICA
影响因子：
--
作者：
LAUREN, P
通讯作者：
LAUREN, P
影响因子：
168.9
作者：
Gianni, Luca;Eiermann, Wolfgang;Baselga, Jose
通讯作者：
Baselga, Jose
影响因子：
3.4
作者：
Zheng, Huachuan;Takahashi, Hiroyuki;Takano, Yasuo
通讯作者：
Takano, Yasuo
影响因子：
2.6
作者：
Kochi M;Fujii M;Masuda S;Kanamori N;Mihara Y;Funada T;Tamegai H;Watanabe M;Suda H;Takayama T
通讯作者：
Takayama T