A transient solution for vesicle electrodeformation and relaxation
A transient solution for vesicle electrodeformation and relaxation
复制标题
囊泡电形成和松弛的瞬态解决方案
DOI：
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Hao Lin
中科院分区：
文献类型：
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作者：
Jia Zhang;Jeffery Zahn;Wenchang Tan;Hao Lin
提出了一种直流电场作用下囊泡变形的瞬态分析方法。该理论从液滴模型延伸，并考虑了将任意性质的两种流体分离的脂质膜。对于后者，提供了膜充电和膜机械模型。假设囊泡始终保持球形。主要结果是一个常微分方程的囊泡纵横比的演变。初始膜张力和脉冲长度的影响进行了研究。模型预测与实验数据进行了广泛的比较，并显示出准确地捕捉系统的行为在没有或弱电穿孔的制度。更重要的是，比较表明，囊泡松弛服从相似律，无论变形的手段。该过程是由一个单一的时间尺度，这是一个功能的囊泡初始半径，流体粘度，和初始膜张力。该相似标度律可用于从实验数据计算膜性质。
A transient analysis for vesicle deformation under direct-current electric fields is developed. The theory extends from a droplet model, with the additional consideration of a lipid membrane separating two fluids of arbitrary properties. For the latter, both a membrane-charging and a membrane-mechanical model are supplied. The vesicle is assumed to remain spheroidal in shape for all times. The main result is an ordinary differential equation governing the evolution of the vesicle aspect ratio. The effects of initial membrane tension and pulse length are examined. The model prediction is extensively compared with experimental data, and is shown to accurately capture the system behavior in the regime of no or weak electroporation. More importantly, the comparison reveals that vesicle relaxation obeys a similarity law regardless of the means of deformation. The process is governed by a single time scale that is a function of the vesicle initial radius, the fluid viscosity, and the initial membrane tension. This similarity scaling law can be used to calculate membrane properties from experimental data.
影响因子：
3.4
作者：
DeBruin, KA;Krassowska, W
通讯作者：
Krassowska, W
影响因子：
3.4
作者：
NEEDHAM, D;HOCHMUTH, RM
通讯作者：
HOCHMUTH, RM